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IPR007857 is a Protein arginine N-methyltransferase PRMT5.
<p>This entry represents a group of arginine N-methyltransferases, including Skb1 from S. pombe [[cite:PUB00073546]], Hsl7 from S. cerevisiae [[cite:PUB00073547]] and their homologues PRMT5 from animals [[cite:PUB00010228], [cite:PUB00020182], [cite:PUB00058186]] and plants [[cite:PUB00073549]]. Skb1 is a mediator of hyperosmotic stress response in Schizosaccharomyces pombe [[cite:PUB00073546]]. Plant PMRT15 is involved in the post-transcriptional regulation of the circadian clock [[cite:PUB00073550]]. Human PRMT5 is a component of multiple protein complexes and contributes to essential cellular processes, such as RNA transport and splicing, cell cycle regulation, tumour growth, and chromatin remodelling, leading to either gene silencing or activation [[cite:PUB00073551]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Protein methylation | The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. | ||
| Molecular function | Methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. | ||
| Biological process | Peptidyl-arginine N-methylation | The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Protein arginine N-methyltransferase [Medicago truncatula] gi|357466465|ref|XP_003603517.1| | 3 | ||
| – | PREDICTED: protein arginine N-methyltransferase 1.5-like [Glycine max] gi|356515519|ref|XP_003526447.1| | 9 | ||
| – | Protein arginine N-methyltransferase; TAIR: AT4G31120.1 SHK1 binding protein 1; Swiss-Prot: sp|Q8GWT4|ANM15_ARATH Protein arginine N-methyltransferase 1.5; TrEMBL-Plants: tr|A0A151SR51|A0A151SR51_CAJCA Protein arginine N-methyltransferase; Found in the gene: LotjaGi1g1v0392200 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF53335 | SUPERFAMILY | 1 | 33.33 |