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IPR007918 is a Mitochondrial distribution/morphology family 35/apoptosis.
<p>This is a family of small highly conserved proteins. In Saccharomyces cerevisiae (Baker's yeast) the gene YKL053C-A (MDM35) [swissprot:O60200] is one of the genes essential for maintenance of normal mitochondrial distribution and morphology (MDM) [[cite:PUB00033261]]; wherease in Homo sapiens (Human), p53CSV, [swissprot:O43715] is a direct transcriptional target for p53 and appears to be a cell-survival mediator in response to genotoxic stress including low-levels of DNA damage. It is suggested that p53CSV modulates the apoptotic pathway through interaction with HSP70 and Apaf-1 thereby inhibiting activation of procaspase-3 and procaspase-9 [[cite:PUB00033262]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Uncharacterized protein TCM_037337 [Theobroma cacao] gi|508782725|gb|EOY29981.1| | 3 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR21329 | PANTHER | 1 | 100.00 |