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IPR008283 is a Peptidase M17, leucyl aminopeptidase, N-terminal.
<p>This group of metallopeptidases belong to the MEROPS peptidase family M17 (leucyl aminopeptidase family, clan MF), the type example being leucyl aminopeptidase from Bos taurus (Bovine).</p> <p>Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation which is usually zinc, but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidases, two metal ions are observed in crystal structures ligated by five amino acids, with one amino acid ligating both metal ions. The known metal ligands are His, Glu, Asp or Lys. At least one other residue is required for catalysis, which may play an electrophillic role. Many metalloproteases contain an HEXXH motif, which has been shown in crystallographic studies to form part of the metal-binding site [[cite:PUB00003579]]. The HEXXH motif is relatively common, but can be more stringently defined for metalloproteases as 'abXHEbbHbc', where 'a' is most often valine or threonine and forms part of the S1' subsite in thermolysin and neprilysin, 'b' is an uncharged residue, and 'c' a hydrophobic residue. Proline is never found in this site, possibly because it would break the helical structure adopted by this motif in metalloproteases [[cite:PUB00003579]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Aminopeptidase activity | Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. | ||
| Biological process | Proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: leucine aminopeptidase 2, chloroplastic-like [Cicer arietinum] gi|502169702|ref|XP_004514667.1| | 23 | ||
| – | Leucine aminopeptidase, putative; TAIR: AT4G30910.1 Cytosol aminopeptidase family protein; Swiss-Prot: sp|Q6K669|AMPL2_ORYSJ Leucine aminopeptidase 2, chloroplastic; TrEMBL-Plants: tr|A0A0B2SEX9|A0A0B2SEX9_GLYSO Leucine aminopeptidase 3, chloroplastic; Found in the gene: LotjaGi3g1v0327400_LC | 8 | ||
| – | Leucine aminopeptidase; TAIR: AT4G30920.1 Cytosol aminopeptidase family protein; Swiss-Prot: sp|Q6K669|AMPL2_ORYSJ Leucine aminopeptidase 2, chloroplastic; TrEMBL-Plants: tr|A0A0B2SEX9|A0A0B2SEX9_GLYSO Leucine aminopeptidase 3, chloroplastic; Found in the gene: LotjaGi3g1v0327400_LC | 8 | ||
| – | Leucine aminopeptidase, putative; TAIR: AT4G30910.1 Cytosol aminopeptidase family protein; Swiss-Prot: sp|Q6K669|AMPL2_ORYSJ Leucine aminopeptidase 2, chloroplastic; TrEMBL-Plants: tr|A0A0B2SEX9|A0A0B2SEX9_GLYSO Leucine aminopeptidase 3, chloroplastic; Found in the gene: LotjaGi3g1v0327400_LC | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF52949 | SUPERFAMILY | 1 | 25.00 |