Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR008383

Description

IPR008383 is a Apoptosis inhibitory 5.

<p>This family consists of apoptosis inhibitory protein 5 (API5) sequences from several organisms. Apoptosis or programmed cell death is a physiological form of cell death that occurs in embryonic development and organ formation. It is characterised by biochemical and morphological changes such as DNA fragmentation and cell volume shrinkage. API5 is an anti apoptosis gene located in Homo sapiens chromosome 11, whose expression prevents the programmed cell death that occurs upon the deprivation of growth factors [[cite:PUB00011539], [cite:PUB00011538]] and is up-regulated in various cancer cells. This protein has an elongated all α-helical structure, in which the N-terminal half is similar to the HEAT repeat and the C-terminal half is similar to the ARM (Armadillo-like) repeat. This suggests that API5 is involved in protein-protein interactions and may act as a scaffold for multiprotein complexes [[cite:PUB00098158]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 5

Transcript Name Description Predicted domains Domain count
PREDICTED: apoptosis inhibitor 5-like [Glycine max] gi|356548640|ref|XP_003542708.1| 4
PREDICTED: apoptosis inhibitor 5-like isoform X4 [Cicer arietinum] gi|502142829|ref|XP_004505121.1| 5
Apoptosis inhibitor 5; TAIR: AT2G34040.1 Apoptosis inhibitory protein 5 (API5); Swiss-Prot: sp|Q6Z6S1|API5_ORYSJ Apoptosis inhibitor 5-like protein API5; TrEMBL-Plants: tr|A0A1J7H470|A0A1J7H470_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0065300 7
Apoptosis inhibitor 5; TAIR: AT2G34040.1 Apoptosis inhibitory protein 5 (API5); Swiss-Prot: sp|Q6Z6S1|API5_ORYSJ Apoptosis inhibitor 5-like protein API5; TrEMBL-Plants: tr|A0A1J7H470|A0A1J7H470_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0065300 7
Apoptosis inhibitor 5; TAIR: AT2G34040.1 Apoptosis inhibitory protein 5 (API5); Swiss-Prot: sp|Q6Z6S1|API5_ORYSJ Apoptosis inhibitor 5-like protein API5; TrEMBL-Plants: tr|A0A1J7H470|A0A1J7H470_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0065300 7

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 20.00