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IPR008758 is a Peptidase S28.
<p>This group of serine peptidases belong to MEROPS peptidase family S28 (clan SC). The predicted active site residues for members of this family and family S10 occur in the same order in the sequence: S, D, H.</p> <p>These serine proteases include several eukaryotic enzymes such as lysosomal Pro-X carboxypeptidase, dipeptidyl-peptidase II, and thymus-specific serine peptidase [[cite:PUB00011654], [cite:PUB00011655], [cite:PUB00011656], [cite:PUB00011657]].</p> <p>Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes [[cite:PUB00003576]]. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identified, these being grouped into clans on the basis of structural similarity and other functional evidence [[cite:PUB00003576]]. Structures are known for members of the clans and the structures indicate that some appear to be totally unrelated, suggesting different evolutionary origins for the serine peptidases [[cite:PUB00003576]].</p> <p>Not withstanding their different evolutionary origins, there are similarities in the reaction mechanisms of several peptidases. Chymotrypsin, subtilisin and carboxypeptidase C have a catalytic triad of serine, aspartate and histidine in common: serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base [[cite:PUB00003576]]. The geometric orientations of the catalytic residues are similar between families, despite different protein folds [[cite:PUB00003576]]. The linear arrangements of the catalytic residues commonly reflect clan relationships. For example the catalytic triad in the chymotrypsin clan (PA) is ordered HDS, but is ordered DHS in the subtilisin clan (SB) and SDH in the carboxypeptidase clan (SC) [[cite:PUB00003576], [cite:PUB00000522]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. | ||
| Molecular function | Serine-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | 10 | |||
| – | 8 | |||
| – | PREDICTED: lysosomal Pro-X carboxypeptidase-like [Cicer arietinum] gi|502152690|ref|XP_004509045.1| | 6 | ||
| – | PREDICTED: lysosomal Pro-X carboxypeptidase-like [Cicer arietinum] gi|502152690|ref|XP_004509045.1| | 4 | ||
| – | PREDICTED: lysosomal Pro-X carboxypeptidase-like [Cicer arietinum] gi|502152690|ref|XP_004509045.1| | 4 | ||
| – | PREDICTED: lysosomal Pro-X carboxypeptidase-like [Cicer arietinum] gi|502152690|ref|XP_004509045.1| | 12 | ||
| – | PREDICTED: lysosomal Pro-X carboxypeptidase-like [Cicer arietinum] gi|502112041|ref|XP_004494225.1| | 13 | ||
| – | Thymus-specific serine protease [Medicago truncatula] gi|357483671|ref|XP_003612122.1| | 14 | ||
| – | PREDICTED: lysosomal Pro-X carboxypeptidase-like [Cicer arietinum] gi|502152690|ref|XP_004509045.1| | 4 | ||
| – | PREDICTED: probable serine protease EDA2-like [Glycine max] gi|356559327|ref|XP_003547951.1| | 4 | ||
| – | Lysosomal pro-X carboxypeptidase-like protein; TAIR: AT2G24280.1 alpha/beta-Hydrolases superfamily protein; Swiss-Prot: sp|Q5RBU7|PCP_PONAB Lysosomal Pro-X carboxypeptidase; TrEMBL-Plants: tr|A0A072U369|A0A072U369_MEDTR Lysosomal pro-X carboxypeptidase-like protein; Found in the gene: LotjaGi1g1v0734400 | 15 | ||
| – | Serine carboxypeptidase S28 family protein; TAIR: AT4G36195.1 Serine carboxypeptidase S28 family protein; Swiss-Prot: sp|Q1PF50|EDA2_ARATH Probable serine protease EDA2; TrEMBL-Plants: tr|I3SCC2|I3SCC2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0383800 | 14 | ||
| – | Serine carboxypeptidase S28 family protein; TAIR: AT4G36195.1 Serine carboxypeptidase S28 family protein; Swiss-Prot: sp|Q1PF50|EDA2_ARATH Probable serine protease EDA2; TrEMBL-Plants: tr|G7KGD8|G7KGD8_MEDTR Serine carboxypeptidase S28 family protein; Found in the gene: LotjaGi2g1v0383800 | 16 | ||
| – | Serine carboxypeptidase S28 family protein; TAIR: AT4G36195.1 Serine carboxypeptidase S28 family protein; Swiss-Prot: sp|Q1PF50|EDA2_ARATH Probable serine protease EDA2; TrEMBL-Plants: tr|G7KGD8|G7KGD8_MEDTR Serine carboxypeptidase S28 family protein; Found in the gene: LotjaGi2g1v0383800 | 9 | ||
| – | Lysosomal Pro-X carboxypeptidase; TAIR: AT5G22860.1 Serine carboxypeptidase S28 family protein; Swiss-Prot: sp|Q2TA14|PCP_BOVIN Lysosomal Pro-X carboxypeptidase; TrEMBL-Plants: tr|A0A151SAK8|A0A151SAK8_CAJCA Lysosomal Pro-X carboxypeptidase; Found in the gene: LotjaGi3g1v0171000 | 6 | ||
| – | Lysosomal Pro-X carboxypeptidase; TAIR: AT5G65760.1 Serine carboxypeptidase S28 family protein; Swiss-Prot: sp|Q5RBU7|PCP_PONAB Lysosomal Pro-X carboxypeptidase; TrEMBL-Plants: tr|A0A059XKX8|A0A059XKX8_CICAR Serine protease; Found in the gene: LotjaGi4g1v0091300 | 9 | ||
| – | Lysosomal Pro-X carboxypeptidase; TAIR: AT5G65760.1 Serine carboxypeptidase S28 family protein; Swiss-Prot: sp|Q5RBU7|PCP_PONAB Lysosomal Pro-X carboxypeptidase; TrEMBL-Plants: tr|V7CCC7|V7CCC7_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0091400 | 17 | ||
| – | Serine carboxypeptidase S28 family protein; TAIR: AT4G36195.1 Serine carboxypeptidase S28 family protein; Swiss-Prot: sp|Q1PF50|EDA2_ARATH Probable serine protease EDA2; TrEMBL-Plants: tr|C6TKC9|C6TKC9_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi4g1v0125200 | 16 | ||
| – | Serine carboxypeptidase S28 family protein; TAIR: AT4G36195.1 Serine carboxypeptidase S28 family protein; Swiss-Prot: sp|Q1PF50|EDA2_ARATH Probable serine protease EDA2; TrEMBL-Plants: tr|C6TKC9|C6TKC9_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi4g1v0125200 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TMhelix | TMHMM | 1 | 5.26 |