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IPR010061 is a Methylmalonate-semialdehyde dehydrogenase.
<p>Methylmalonate-semialdehyde dehydrogenase (MMSDH,[ec:1.2.1.27]) catalyses the irreversible NAD+- and CoA-dependent oxidative decarboxylation of methylmalonate semialdehyde to propionyl-CoA. Methylmalonate-semialdehyde dehydrogenase has been characterised in both prokaryotes [[cite:PUB00002721], [cite:PUB00013470]] and eukaryotes [[cite:PUB00013471]], functioning as a mammalian tetramer and a bacterial homodimer. Although similar in monomeric molecular mass and enzymatic activity, the N-terminal sequence in Pseudomonas aeruginosa does not correspond with the N-terminal sequence predicted for rat liver. Sequence homology to a variety of prokaryotic and eukaryotic aldehyde dehydrogenases places MMSDH in the aldehyde dehydrogenase (NAD+) superfamily making MMSDH's CoA requirement unique among known ALDHs. Methylmalonate semialdehyde dehydrogenase is closely related to betaine aldehyde dehydrogenase, 2-hydroxymuconic semialdehyde dehydrogenase, and class 1 and 2 aldehyde dehydrogenase [[cite:PUB00013471]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Methylmalonate-semialdehyde dehydrogenase (acylating) activity | Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: methylmalonate-semialdehyde dehydrogenase [acylating] gi|356521227|ref|XP_003529258.1| | 20 | ||
| – | PREDICTED: methylmalonate-semialdehyde dehydrogenase [acylating] gi|356524788|ref|XP_003531010.1| | 15 | ||
| – | FAR1 DNA-binding domain protein; TAIR: AT5G64170.1 dentin sialophosphoprotein-like protein; Swiss-Prot: sp|P11862|GAS2_MOUSE Growth arrest-specific protein 2; TrEMBL-Plants: tr|A0A0B2RHZ3|A0A0B2RHZ3_GLYSO Uncharacterized protein; Found in the gene: LotjaGi1g1v0043100_LC | 3 | ||
| – | FAR1 DNA-binding domain protein; TAIR: AT2G36380.1 pleiotropic drug resistance 6; Swiss-Prot: sp|Q7PC87|AB34G_ARATH ABC transporter G family member 34; TrEMBL-Plants: tr|A0A0B2RHZ3|A0A0B2RHZ3_GLYSO Uncharacterized protein; Found in the gene: LotjaGi2g1v0071000_LC | 3 | ||
| – | FAR1 DNA-binding domain protein; TAIR: AT1G54010.1 GDSL-like Lipase/Acylhydrolase superfamily protein; Swiss-Prot: sp|O75309|CAD16_HUMAN Cadherin-16; TrEMBL-Plants: tr|A0A0S3S7D4|A0A0S3S7D4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0294000_LC | 3 | ||
| – | Aldehyde dehydrogenase; TAIR: AT2G14170.1 aldehyde dehydrogenase 6B2; Swiss-Prot: sp|Q0WM29|MMSA_ARATH Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; TrEMBL-Plants: tr|I1KL66|I1KL66_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0040900 | 21 | ||
| – | Aldehyde dehydrogenase; TAIR: AT2G14170.1 aldehyde dehydrogenase 6B2; Swiss-Prot: sp|Q0WM29|MMSA_ARATH Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; TrEMBL-Plants: tr|I1KL66|I1KL66_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0040900 | 21 | ||
| – | Aldehyde dehydrogenase; TAIR: AT2G14170.1 aldehyde dehydrogenase 6B2; Swiss-Prot: sp|Q0WM29|MMSA_ARATH Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; TrEMBL-Plants: tr|G7JU35|G7JU35_MEDTR Methylmalonate-semialdehyde dehydrogenase; Found in the gene: LotjaGi4g1v0040900 | 15 | ||
| – | Aldehyde dehydrogenase; TAIR: AT2G14170.1 aldehyde dehydrogenase 6B2; Swiss-Prot: sp|Q0WM29|MMSA_ARATH Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; TrEMBL-Plants: tr|G7JU35|G7JU35_MEDTR Methylmalonate-semialdehyde dehydrogenase; Found in the gene: LotjaGi4g1v0040900 | 15 | ||
| – | Isocitrate dehydrogenase kinase/phosphatase; TAIR: AT1G54010.1 GDSL-like Lipase/Acylhydrolase superfamily protein; Swiss-Prot: sp|B7UPG7|ACEK_ECO27 Isocitrate dehydrogenase kinase/phosphatase; TrEMBL-Plants: tr|A0A0B2QX27|A0A0B2QX27_GLYSO Protein FAR1-RELATED SEQUENCE 6; Found in the gene: LotjaGi4g1v0336500_LC | 3 | ||
| – | FAR1 DNA-binding domain protein; TAIR: AT4G27180.1 kinesin 2; Swiss-Prot: sp|B7UPG7|ACEK_ECO27 Isocitrate dehydrogenase kinase/phosphatase; TrEMBL-Plants: tr|A0A0S3S7D4|A0A0S3S7D4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0079700_LC | 3 | ||
| – | Aldehyde dehydrogenase; TAIR: AT2G14170.1 aldehyde dehydrogenase 6B2; Swiss-Prot: sp|Q0WM29|MMSA_ARATH Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; TrEMBL-Plants: tr|A0A1J7GWW1|A0A1J7GWW1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0348500 | 15 | ||
| – | Aldehyde dehydrogenase; TAIR: AT2G14170.1 aldehyde dehydrogenase 6B2; Swiss-Prot: sp|Q0WM29|MMSA_ARATH Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; TrEMBL-Plants: tr|A0A1J7GWW1|A0A1J7GWW1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0348500 | 15 | ||
| – | Aldehyde dehydrogenase; TAIR: AT2G14170.1 aldehyde dehydrogenase 6B2; Swiss-Prot: sp|Q0WM29|MMSA_ARATH Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; TrEMBL-Plants: tr|I3T9T5|I3T9T5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0348500 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07085 | CDD | 1 | 7.14 |