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IPR010084 is a Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ.
<p>Fatty acids biosynthesis occurs by two distinct pathways: in fungi, mammals and mycobacteria, type I or associative fatty-acid biosynthesis (type I FAS) is accomplished by multifunctional proteins in which distinct domains catalyse specific reactions; in plants and most bacteria, type II or dissociative fatty-acid biosynthesis (type II FAS) is accomplished by distinct enzymes [[cite:PUB00014939]].</p> <p>FabZ is the primary dehydratase involved in fatty-acid elongation in type II FAS. Both FabZ and FabA catalyse the dehydration of beta-hydroxyacyl acyl carrier protein (ACP) to trans 2-enoyl ACP. However, FabZ and FabA display subtle differences in substrate specificities, whereby FabA is most effective on acyl ACPs of 9-11 carbon atoms in length, while FabZ is less specific. Unlike FabA, FabZ does not function as an isomerase and cannot initiate unsaturated fatty acid biosynthesis. However, only FabZ can act during the elongation of unsaturated fatty acid chains.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Fatty acid biosynthetic process | The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. | ||
| Molecular function | Hydro-lyase activity | Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: (3R)-hydroxymyristoyl-[acyl]-carrier-protein] gi|356558645|ref|XP_003547614.1| | 11 | ||
| – | 3-hydroxyacyl-[acyl]-carrier-protein] dehydratase FabZ; TAIR: AT5G10160.1 Thioesterase superfamily protein; Swiss-Prot: sp|P73848|FABZ_SYNY3 3-hydroxyacyl-[acyl]-carrier-protein] dehydratase FabZ; TrEMBL-Plants: tr|I3T5Z3|I3T5Z3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0033600 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01288 | CDD | 1 | 50.00 |