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IPR010102 is a Succinate semialdehyde dehydrogenase.
<p>Succinate semialdehyde dehydrogenase (SSADH) is one of three enzymes constituting 4-aminobutyrate (GABA) degradation in both prokaryotes and eukaryotes, catalysing the (NAD(P)+)-dependent catabolism reaction of succinate semialdehyde to succinate for metabolism by the citric acid cycle. In Escherichia coli, SSADH is located in a unidirectionally transcribed gene cluster encoding enzymes for GABA degradation and is suggested to be co-transcribed with succinate semialdehyde transaminase from a common promoter upstream of SSADH [[cite:PUB00000167]]. Similar gene arrangements can be found in characterised Ralstonia eutropha (Alcaligenes eutrophus) [[cite:PUB00013487]] and the genome analysis of Bacillus subtilis.</p> <p>Prokaryotic SSADH enzymes ([ec:1.2.1.16]) share high sequence homology to characterised SSADH from rat and human ([ec:1.2.1.24]), exhibiting conservation of proposed cofactor binding residues, and putative active sites (G-237 and G-242, C-293 and G-259 respectively of rat SSADH) [[cite:PUB00013488]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Succinate-semialdehyde dehydrogenase [NAD(P)+] activity | Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+. | ||
| Biological process | Gamma-aminobutyric acid catabolic process | The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Aldehyde dehydrogenase; TAIR: AT1G79440.1 aldehyde dehydrogenase 5F1; Swiss-Prot: sp|Q9SAK4|SSDH_ARATH Succinate-semialdehyde dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A0R4J5H1|A0A0R4J5H1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0132700 | 17 | ||
| – | Aldehyde dehydrogenase; TAIR: AT1G79440.1 aldehyde dehydrogenase 5F1; Swiss-Prot: sp|Q9SAK4|SSDH_ARATH Succinate-semialdehyde dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A0R4J5H1|A0A0R4J5H1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0132700 | 22 | ||
| – | Aldehyde dehydrogenase; TAIR: AT1G79440.1 aldehyde dehydrogenase 5F1; Swiss-Prot: sp|Q9SAK4|SSDH_ARATH Succinate-semialdehyde dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A0R4J5H1|A0A0R4J5H1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0132700 | 17 | ||
| – | Aldehyde dehydrogenase; TAIR: AT1G79440.1 aldehyde dehydrogenase 5F1; Swiss-Prot: sp|Q9SAK4|SSDH_ARATH Succinate-semialdehyde dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A0R4J5H1|A0A0R4J5H1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0132700 | 17 | ||
| – | Aldehyde dehydrogenase; TAIR: AT1G79440.1 aldehyde dehydrogenase 5F1; Swiss-Prot: sp|Q9SAK4|SSDH_ARATH Succinate-semialdehyde dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A0R4J5H1|A0A0R4J5H1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0132700 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07103 | CDD | 1 | 20.00 |