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IPR012134

Source: InterPro

Description

IPR012134 is a Glutamate-5-semialdehyde dehydrogenase.

<p>Gamma-glutamyl phosphate reductase (GPR), also known as glutamate-5-semialdehyde dehydrogenase, catalyses the second step of proline biosynthesis, the NADPH-dependent reversible reduction of gamma-glutamyl phosphate to glutamate-5-semialdehyde as shown below.</p> <p><reaction>L-glutamyl 5-phosphate + NADPH + H(+) = L-glutamate 5-semialdehyde + phosphate + NADP(+)</reaction></p> <p>In bacteria and yeast, GPR is a monofunctional protein, while in plants and mammals, it is part of a bifunctional enzyme that consists of two domains, an N-terminal glutamate 5-kinase domain ([ec:2.7.2.11]) and a C-terminal GPR domain [[cite:PUB00033269], [cite:PUB00005656], [cite:PUB00004804]].</p> <p>This entry represents the monofunctional gamma-glutamyl phosphate reductase found in bacteria and yeasts. Structural studies indicate that this protein is composed of three domains and belongs to the aldehyde dehydrogenase structural family [[cite:PUB00029304]]. The first two domains, the catalytic and cofactor binding domains respectively, both form a similar three layered α-β-α fold, and are thought to close around the NADPH and gamma-glutamyl-phosphate ligands upon binding in order to orient a conserved cysteine residue for catalysis. The third domain is the oligomerisation domain which forms an antiparallel β sheet. The biological oligomerisation state of the protein is not currently known, but like most members of the aldehyde dehydrogenase family it is expected to be either a dimer or a tetramer.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004350
Molecular function Glutamate-5-semialdehyde dehydrogenase activity Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH.
Subterm of
GO:0006561
Biological process Proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
Subterm of
GO:0050661
Molecular function NADP binding Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
Subterm of
GO:0055114
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
Lj0g3v0115579.1
– Delta-pyrroline-5-carboxylate synthetase [Lespedeza potaninii] gi|411117725|gb|AFW04294.1|
Domains
17

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR00407 TIGRFAM 1 100.00