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IPR012932 is a Vitamin K epoxide reductase.
<p>Vitamin K epoxide reductase (VKOR) recycles vitamin K 2,3-epoxide to vitamin K hydroquinone, a co-factor that is essential for the posttranslational γ-carboxylation of several blood coagulation factors [[cite:PUB00057396]]. VKORC1, the catalytic subunit of the VKOR complex, is a member of a large family of predicted enzymes that are present in vertebrates, Drosophila, plants, bacteria and archaea [[cite:PUB00016407], [cite:PUB00096863]]. Bacterial VKOR homologues catalyse disulphide bridge formation in secreted proteins by cooperating with a periplasmic, Trx-like redox partner [[cite:PUB00057392], [cite:PUB00057393]]. In fact, in some plant and bacterial homologues the VKORC1 homologous domain is fused with domains of the thioredoxin family of oxidoreductases [[cite:PUB00016407]]. VKOR is part of a disulphide bond formation pathway that uses electrons from cysteines of newly synthesized proteins to reduce a quinone [[cite:PUB00055212]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | NAD(P)H dehydrogenase (quinone)s [Arabidopsis thaliana] gi|18419647|ref|NP_567988.1| | 13 | ||
| – | NAD(P)H dehydrogenase (quinone)s [Arabidopsis thaliana] gi|18419647|ref|NP_567988.1| | 13 | ||
| – | NAD(P)H dehydrogenase (quinone)s [Arabidopsis thaliana] gi|18419647|ref|NP_567988.1| | 4 | ||
| – | Thiol-disulfide oxidoreductase LTO1; TAIR: AT4G35760.1 NAD(P)H dehydrogenase (quinone)s; Swiss-Prot: sp|Q8L540|LTO1_ARATH Thiol-disulfide oxidoreductase LTO1; TrEMBL-Plants: tr|A0A151THZ0|A0A151THZ0_CAJCA Uncharacterized protein; Found in the gene: LotjaGi2g1v0376700 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd12916 | CDD | 1 | 25.00 |