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IPR014183 is a Alcohol dehydrogenase class III.
<p>Class III alcohol dehydrogenases (ADH3) ([ec:1.1.1.1]) tend to show poor activity for ethanol among their various substrate alcohols. They catalyze the oxidation and reduction of a wide variety of substrates that include S-(hydroxymethyl)glutathione (HMGSH), S-nitrosoglutathione, and long chain primary alcohols and aldehydes [[cite:PUB00080657]]. The enzyme was previously designated as glutathione-dependent formaldehyde dehydrogenase, as it acts as a HMGSH dehydrogenase ([ec:1.1.1.284]). ADH3 oxidizes HMGSH to S-formylglutathione, which is then hydrolyzed to glutathione and formate by a hydrolase [[cite:PUB00080658], [cite:PUB00080659]]. S-(hydroxymethyl)glutathione can form spontaneously from formaldehyde and glutathione, and constitutes a cellular strategy for sequestering and metabolizing highly toxic formaldehyde [[cite:PUB00027294]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Ethanol oxidation | An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate. | ||
| Molecular function | Zinc ion binding | Interacting selectively and non-covalently with zinc (Zn) ions. | ||
| Molecular function | S-(hydroxymethyl)glutathione dehydrogenase activity | Catalysis of the reaction: S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: alcohol dehydrogenase class-3-like [Cicer arietinum] gi|502114773|ref|XP_004495047.1| | 18 | ||
| – | PREDICTED: alcohol dehydrogenase class-3-like [Cicer arietinum] gi|502110273|ref|XP_004493841.1| | 18 | ||
| – | Alcohol dehydrogenase; TAIR: AT5G43940.1 GroES-like zinc-binding dehydrogenase family protein; Swiss-Prot: sp|Q96533|ADHX_ARATH Alcohol dehydrogenase class-3; TrEMBL-Plants: tr|I3ST14|I3ST14_LOTJA S-(hydroxymethyl)glutathione dehydrogenase; Found in the gene: LotjaGi1g1v0702400 | 17 | ||
| – | Alcohol dehydrogenase; TAIR: AT5G43940.1 GroES-like zinc-binding dehydrogenase family protein; Swiss-Prot: sp|P80572|ADHX_PEA Alcohol dehydrogenase class-3; TrEMBL-Plants: tr|A0A072VKC1|A0A072VKC1_MEDTR S-(hydroxymethyl)glutathione dehydrogenase; Found in the gene: LotjaGi5g1v0152100 | 17 | ||
| – | Alcohol dehydrogenase; TAIR: AT5G43940.1 GroES-like zinc-binding dehydrogenase family protein; Swiss-Prot: sp|Q96533|ADHX_ARATH Alcohol dehydrogenase class-3; TrEMBL-Plants: tr|A0A072VKC1|A0A072VKC1_MEDTR S-(hydroxymethyl)glutathione dehydrogenase; Found in the gene: LotjaGi5g1v0152100 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd08300 | CDD | 1 | 20.00 |