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IPR014644

Source: InterPro

Description

IPR014644 is a Protein arginine N-methyltransferase PRMT7.

<p>This entry represents protein arginine N-methyltransferase PRMT7 [[cite:PUB00058102]].</p> <p>PRMT7 can catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. It mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. It also mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. It plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. It may also play a role in embryonic stem cell (ESC) pluripotency [[cite:PUB00058102], [cite:PUB00058185], [cite:PUB00058186], [cite:PUB00058187]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006479
Biological process Protein methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
Subterm of
GO:0008168
Molecular function Methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi4g1v0203700.1
– Arginine N-methyltransferase; TAIR: AT4G16570.1 protein arginine methyltransferase 7; Swiss-Prot: sp|Q944R7|ANM16_ARATH Protein arginine N-methyltransferase 1.6; TrEMBL-Plants: tr|I1K0P7|I1K0P7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0203700
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF53335 SUPERFAMILY 1 100.00