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IPR014806 is a Ubiquitin-fold modifier-conjugating enzyme 1.
<p>Ubiquitin-like (UBL) post-translational modifiers are covalently linked to most, if not all, target protein(s) through an enzymatic cascade analogous to ubiquitylation, consisting of E1 (activating), E2 (conjugating), and E3 (ligating) enzymes. Ubiquitin-fold modifier 1 (Ufm1) a ubiquitin-like protein is activated by a novel E1-like enzyme, Uba5, by forming a high-energy thioester bond. Activated Ufm1 is then transferred to its cognate E2-like enzyme, Ufc1, in a similar thioester linkage. This family represents the E2-like enzyme which catalyses the second step in ufmylation [[cite:PUB00034740], [cite:PUB00095668]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Ubiquitin-fold modifier-conjugating enzyme [Medicago truncatula] gi|357466793|ref|XP_003603681.1| | 7 | ||
| – | Ubiquitin-fold modifier-conjugating enzyme 1; TAIR: AT1G27530.1 ubiquitin-fold modifier-conjugating enzyme; Swiss-Prot: sp|Q9SXC8|UFC1_ARATH Ubiquitin-fold modifier-conjugating enzyme 1; TrEMBL-Plants: tr|I3S498|I3S498_LOTJA Ubiquitin-fold modifier-conjugating enzyme 1; Found in the gene: LotjaGi1g1v0413700 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF54495 | SUPERFAMILY | 1 | 50.00 |