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IPR015056

Source: InterPro

Description

IPR015056 is a Nuclear receptor-binding factor 2, C-terminal.

<p>Nuclear receptor-binding factor 2 (NRBF2) plays an essential role in autophagy, the cellular pathway that degrades long-lived proteins and other cytoplasmic contents through lysosomes. NRBF2 binds Atg14L - a Beclin-binding protein - directly via the MIT domain and enhances Atg14L-linked Vps34 kinase (a class III phosphatidylinositol-3 kinase) activity and autophagy induction [[cite:PUB00078727], [cite:PUB00078728]].</p> <p>This entry represents the C-terminal domain of NRBF2.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006914
Biological process Autophagy The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj1g3v3881740.1
– PREDICTED: protein CHUP1, chloroplastic-like [Glycine max] gi|356498962|ref|XP_003518314.1|
Domains
7
LotjaGi1g1v0117700.1
– Protein CHUP1, chloroplastic; TAIR: AT1G07120.1 CHUP1-like protein; Swiss-Prot: sp|Q9LI74|CHUP1_ARATH Protein CHUP1, chloroplastic; TrEMBL-Plants: tr|A0A0S3RLT5|A0A0S3RLT5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0117700
Domains
7

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00