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IPR015864

Source: InterPro

Description

IPR015864 is a FAD synthetase.

<p>Riboflavin is converted into catalytically active cofactors (FAD and FMN) by the actions of riboflavin kinase ([ec:2.7.1.26]), which converts it into FMN, and FAD synthetase ([ec:2.7.7.2]), which adenylates FMN to FAD. Eukaryotes usually have two separate enzymes, while most prokaryotes have a single bifunctional protein that can carry out both catalyses, although exceptions occur in both cases. While eukaryotic monofunctional riboflavin kinase is orthologous to the bifunctional prokaryotic enzyme [[cite:PUB00030175]], the monofunctional FAD synthetase differs from its prokaryotic counterpart, and is instead related to the PAPS-reductase family [[cite:PUB00035657]]. The bacterial FAD synthetase that is part of the bifunctional enzyme has remote similarity to nucleotidyl transferases and, hence, it may be involved in the adenylylation reaction of FAD synthetases [[cite:PUB00010127]].</p> <p>This entry represents prokaryotic-type FAD synthetase, which occurs primarily as part of a bifunctional enzyme.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003919
Molecular function FMN adenylyltransferase activity Catalysis of the reaction: ATP + FMN = diphosphate + FAD.
Subterm of
GO:0009231
Biological process Riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
Lj5g3v2259640.1
– PREDICTED: riboflavin biosynthesis protein RibF-like [Fragaria vesca subsp]. vesca] gi|470123411|ref|XP_004297720.1|
Domains
7

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF52374 SUPERFAMILY 1 100.00