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IPR019442

Source: InterPro

Description

IPR019442 is a THADA/TRM732, DUF2428.

<p>This conserved domain is found in Thyroid adenoma-associated protein (THADA) from animals and in the yeast homologue tRNA (cytidine(32)-2'-O)-methyltransferase non-catalytic subunit TRM732 [[cite:PUB00098320], [cite:PUB00098321], [cite:PUB00098322]]. Trm732 forms a complex with the methyltransferase Trm7 to 2'- O- methylate tRNA residue 32 (Nm32), being required for Trm7 methylation activity. In humans, mutations of the Trm7 homologue FTSJ1, which interacts with THADA, impair Nm32 modifications, associated with non-syndromic X-linked intellectual disability [[cite:PUB00098320], [cite:PUB00098321], [cite:PUB00098322]]. It has been suggested that these proteins may play a role in additional biological processes not related to translation. This domain contains a RRSAGLP conserved motif that is required for tRNA modification activity (Funk HM et.al., Preprint from bioRxiv, 03 Jun 2021 DOI: 10.1101/2021.06.03.446962) [[cite:PUB00098320], [cite:PUB00098321], [cite:PUB00098322]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
Lj2g3v1056980.1
– PREDICTED: thyroid adenoma-associated protein homolog [Cicer arietinum] gi|502090932|ref|XP_004489387.1|
Domains
4
Lj2g3v1056980.2
– PREDICTED: thyroid adenoma-associated protein homolog [Cicer arietinum] gi|502090932|ref|XP_004489387.1|
Domains
4
Lj2g3v1056980.3
– PREDICTED: thyroid adenoma-associated protein homolog [Cicer arietinum] gi|502090932|ref|XP_004489387.1|
Domains
4
LotjaGi2g1v0258400.1
– Thyroid adenoma-associated protein-like protein; TAIR: AT3G55160.1 thyroid adenoma-associated-like protein; Swiss-Prot: sp|A8C750|THADA_CANLF Thyroid adenoma-associated protein homolog; TrEMBL-Plants: tr|A0A072U7B4|A0A072U7B4_MEDTR Death receptor interacting protein, putative; Found in the gene: LotjaGi2g1v0258400
Domains
6
LotjaGi2g1v0259800_LC.1
– Thyroid adenoma-associated protein; TAIR: AT3G55160.1 thyroid adenoma-associated-like protein; Swiss-Prot: sp|A8C756|THADA_MOUSE Thyroid adenoma-associated protein homolog; TrEMBL-Plants: tr|A0A151S7W6|A0A151S7W6_CAJCA Thyroid adenoma-associated protein isogeny; Found in the gene: LotjaGi2g1v0259800_LC
Domains
5
LotjaGi2g1v0259800_LC.2
– Thyroid adenoma-associated protein; TAIR: AT3G55160.1 thyroid adenoma-associated-like protein; Swiss-Prot: sp|A8C756|THADA_MOUSE Thyroid adenoma-associated protein homolog; TrEMBL-Plants: tr|A0A151S7W6|A0A151S7W6_CAJCA Thyroid adenoma-associated protein isogeny; Found in the gene: LotjaGi2g1v0259800_LC
Domains
5

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 16.67