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IPR020464 is a LanC-like protein, eukaryotic.
<p>The LanC-like protein superfamily encompasses a highly divergent group of peptide-modifying enzymes, including the eukaryotic and bacterial lanthionine synthetase C-like proteins (LanC) [[cite:PUB00046016], [cite:PUB00046017], [cite:PUB00046018]]; subtilin biosynthesis protein SpaC from Bacillus subtilis [[cite:PUB00002161], [cite:PUB00008599]]; epidermin biosynthesis protein EpiC from Staphylococcus epidermidis [[cite:PUB00018966]]; nisin biosynthesis protein NisC from Lactococcus lactis [[cite:PUB00011680], [cite:PUB00046051], [cite:PUB00046021]]; GCR2 from Arabidopsis thaliana (Mouse-ear cress) [[cite:PUB00035552]]; and many others.</p> <p>The 3D structure of the lantibiotic cyclase from L. lactis has been determined by X-ray crystallography to 2.5A resolution [[cite:PUB00040886]]. The globular structure is characterised by an all-α fold, in which an outer ring of helices envelops an inner toroid composed of 7 shorter, hydrophobic helices. This 7-fold hydrophobic periodicity has led several authors to claim various members of the family, including eukaryotic LanC-1 and GCR2, to be novel G protein-coupled receptors [[cite:PUB00035552], [cite:PUB00046022]]; some of these claims have since been corrected [[cite:PUB00046017], [cite:PUB00046023], [cite:PUB00046024]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: lanC-like protein 2-like [Glycine max] gi|356542916|ref|XP_003539910.1| | 12 | ||
| – | PREDICTED: lanC-like protein 2-like [Cicer arietinum] gi|502168772|ref|XP_004514463.1| | 13 | ||
| – | PREDICTED: lanC-like protein 2 [Vitis vinifera] gi|225461385|ref|XP_002284781.1| | 10 | ||
| – | PREDICTED: lanC-like protein 2-like [Cicer arietinum] gi|502135650|ref|XP_004502406.1| | 10 | ||
| – | LanC-like protein; TAIR: AT1G52920.1 G protein coupled receptor; Swiss-Prot: sp|F4IEM5|GCR2_ARATH LanC-like protein GCR2; TrEMBL-Plants: tr|A0A0L9UM49|A0A0L9UM49_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0076500 | 12 | ||
| – | LanC-like protein; TAIR: AT2G20770.1 GCR2-like 2; Swiss-Prot: sp|Q8VZQ6|GCL2_ARATH LanC-like protein GCL2; TrEMBL-Plants: tr|G7KIT8|G7KIT8_MEDTR G protein coupled receptor; Found in the gene: LotjaGi3g1v0455700 | 12 | ||
| – | LanC-like protein 2; TAIR: AT2G20770.1 GCR2-like 2; Swiss-Prot: sp|Q8VZQ6|GCL2_ARATH LanC-like protein GCL2; TrEMBL-Plants: tr|G7KIT8|G7KIT8_MEDTR G protein coupled receptor; Found in the gene: LotjaGi3g1v0455700 | 12 | ||
| – | LanC-like protein 2; TAIR: AT2G20770.1 GCR2-like 2; Swiss-Prot: sp|Q8VZQ6|GCL2_ARATH LanC-like protein GCL2; TrEMBL-Plants: tr|G7KIT8|G7KIT8_MEDTR G protein coupled receptor; Found in the gene: LotjaGi3g1v0455800 | 13 | ||
| – | LanC-like protein; TAIR: AT5G65280.1 GCR2-like 1; Swiss-Prot: sp|Q9FJN7|GCL1_ARATH LanC-like protein GCL1; TrEMBL-Plants: tr|G7J384|G7J384_MEDTR G protein coupled receptor; Found in the gene: LotjaGi6g1v0092000 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04794 | CDD | 1 | 11.11 |