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IPR020789

Source: InterPro

Description

IPR020789 is a RNA polymerases, subunit N, zinc binding site.

<p>In eukaryotes, there are three different forms of DNA-dependent RNA polymerases ([ec:2.7.7.6]) transcribing different sets of genes. Each class of RNA polymerase is an assemblage of ten to twelve different polypeptides. In archaebacteria, there is generally a single form of RNA polymerase which also consists of an oligomeric assemblage of 10 to 13 polypeptides. Archaebacterial subunit N (gene rpoN) [[cite:PUB00004866]] is a small protein of about 8kDa, it is evolutionary related [[cite:PUB00002250]] to a 8.3kDa component shared by all three forms of eukaryotic RNA polymerases (gene RPB10 in yeast and POLR2J in mammals) as well as to African swine fever virus (ASFV) protein CP80R [[cite:PUB00015097]].</p> <p>This signature spans the conserved region, which is located at the N-terminal extremity of these polymerase subunits; this region contains two cysteines that binds a zinc ion [[cite:PUB00015096]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003677
Molecular function DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
Subterm of
GO:0003899
Molecular function DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
Subterm of
GO:0006351
Biological process Transcription, DNA-templated The cellular synthesis of RNA on a template of DNA.
Subterm of
Part of
GO:0008270
Molecular function Zinc ion binding Interacting selectively and non-covalently with zinc (Zn) ions.
Subterm of

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
Lj0g3v0199369.1
– PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC5-like [Cucumis sativus] gi|449441830|ref|XP_004138685.1|
Domains
13
Lj2g3v1414960.1
– PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC5-like [Cucumis sativus] gi|449441830|ref|XP_004138685.1|
Domains
13
Lj2g3v1468350.1
– PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC5-like [Cucumis sativus] gi|449441830|ref|XP_004138685.1|
Domains
13
Lj2g3v1758390.1
– DNA-directed RNA polymerases I/II/III subunit [Chlamydomonas reinhardtii] gi|159470673|ref|XP_001693481.1|
Domains
12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 25.00