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IPR021643 is a Mediator complex, subunit Med13, N-terminal.
<p>This entry represents the N-terminal domain of Med13.</p> <p>Mediator is a large complex of up to 33 proteins that is conserved from plants through fungi to humans - the number and representation of individual subunits varying with species [[cite:PUB00012328], [cite:PUB00033372]]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Med13 is part of the ancillary kinase module, together with Med12, CDK8 and CycC, which in yeast is implicated in transcriptional repression, though most of this activity is likely attributable to the CDK8 kinase. The large Med12 and Med13 proteins are required for specific developmental processes in Drosophila [[cite:PUB00094411]], zebrafish, and Caenorhabditis elegans but their biochemical functions are not understood [[cite:PUB00053524]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Mediator of RNA polymerase II transcription subunit 13 like; TAIR: AT1G55325.2 RNA polymerase II transcription mediator; Swiss-Prot: sp|F4I096|MED13_ARATH Mediator of RNA polymerase II transcription subunit 13; TrEMBL-Plants: tr|A0A0R0HVT6|A0A0R0HVT6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0031200 | 9 | ||
| – | Mediator of RNA polymerase II transcription subunit 13 like; TAIR: AT1G55325.3 RNA polymerase II transcription mediator; Swiss-Prot: sp|F4I096|MED13_ARATH Mediator of RNA polymerase II transcription subunit 13; TrEMBL-Plants: tr|K7K0Q7|K7K0Q7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0031200 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |