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IPR022043 is a Chromatin assembly factor 1 subunit A.
<p>The CAF-1 or chromatin assembly factor-1 consists of three subunits, and this is the first, or A [[cite:PUB00053560]]. The A domain is uniquely required for the progression of S phase in mouse cells [[cite:PUB00053561]], independent of its ability to promote histone deposition [[cite:PUB00053560]] but dependent on its ability to interact with HP1 - heterochromatin protein 1-rich heterochromatin domains next to centromeres that are crucial for chromosome segregation during mitosis. This HP1-CAF-1 interaction module functions as a built-in replication control for heterochromatin, which, like a control barrier, has an impact on S-phase progression in addition to DNA-based checkpoints [[cite:PUB00053561]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: chromatin assembly factor 1 subunit FAS1-like isoform X2 [Cicer arietinum] gi|502105709|ref|XP_004492868.1| | 6 | ||
| – | Chromatin assembly factor 1 subunit A; TAIR: AT1G65470.1 chromatin assembly factor-1 (FASCIATA1) (FAS1); Swiss-Prot: sp|Q9SXY0|FAS1_ARATH Chromatin assembly factor 1 subunit FAS1; TrEMBL-Plants: tr|I1N414|I1N414_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0488100 | 6 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |