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IPR022100 is a WDHD1/CFT4, second beta-propeller.
<p>This entry represents the second β-propeller domain found in the middle region of WDHD1 (also known as AND-1) from human and at the C-terminal of its orthologues from yeast, CFT4 and minichromosome loss protein 1 (Mcl1) [[28381552]]. This domain, together with the helical bundle ([interpro:IPR048591]) forms the SepB domain, which mediates the homotrimer formation of these proteins [[28381552]].</p> <p>WDHD1 is an adaptor molecule crucial for DNA replication [[cite:PUB00151993], [cite:PUB00154917]]. It is a core replisome component that acts as a replication initiation factor. It binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork [[cite:PUB00151993], [cite:PUB00151996]].</p> <p>CTF4 is an accessory factor for DNA replication that plays a role in accurately duplicating the genome in vivo [[cite:PUB00151993], [cite:PUB00151996]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: LOW QUALITY PROTEIN: WD repeat and HMG-box DNA-binding protein 1-like [Cicer arietinum] gi|502181680|ref|XP_004516862.1| | 17 | ||
| – | WD-repeat protein, putative; TAIR: AT3G42660.1 transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|O13046|WDHD1_XENLA WD repeat and HMG-box DNA-binding protein 1; TrEMBL-Plants: tr|G7IT11|G7IT11_MEDTR Transducin family protein/WD-40 repeat protein; Found in the gene: LotjaGi1g1v0208800 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |