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IPR024192 is a Fosfomycin resistance kinase, FomA-type.
<p>This entry represents a group of isopentenyl phosphate kinases (IPKs) from archaea and plants. They catalyze the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids [[cite:PUB00073601], [cite:PUB00101688]]. This entry also includes FomA protein from Streptomyces. IPKs and FomA are architecturally very similar [[cite:PUB00101689]].</p> <p>Fosfomycin (L-(cis)-1,2-epoxy propyl phosphonic acid) is an antibiotic produced by some species of Streptomyces and Pseudomonas. As an analogue of phosphoenolpyruvate (PEP), this compound irreversibly inhibits PEP UDP-N-acetylglucosamine-3-O-enolpyruvyltransferase (enolpyruvyltransferase), which catalyses the first step of peptidoglycan biosynthesis [[cite:PUB00014686]]. FomA is one of the fosfomycin resistance kinases. Together with FomB (encoded in the fosfomycin biosynthetic gene cluster of Streptomyces wedmorensis), FomA confer fosfomycin resistance on Escherichia coli [[cite:PUB00014686]]. FomA catalyses phosphorylation of fosfomycin to fosfomycin monophosphate, and FomB phosphorylation of fosfomycin monophosphate to fosfomycin diphosphate, in the presence of ATP and a magnesium ion [[cite:PUB00014686]]. Surprisingly, while FomA homologues are present in many organisms, including fosfomycin-producing ones, no homologues of FomB are detected to date.</p> <p>FomA and related sequences are members of the Amino Acid Kinase Superfamily (AAK).</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Kinase activity | Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Glutamate 5-kinase [Medicago truncatula] gi|357487315|ref|XP_003613945.1| | 10 | ||
| – | Glutamate 5-kinase; TAIR: AT1G26640.1 Amino acid kinase family protein; Swiss-Prot: sp|O26153|IPK_METTH Isopentenyl phosphate kinase; TrEMBL-Plants: tr|A0A0B2P2T3|A0A0B2P2T3_GLYSO Uncharacterized protein; Found in the gene: LotjaGi2g1v0299100 | 11 | ||
| – | Glutamate 5-kinase; TAIR: AT1G26640.1 Amino acid kinase family protein; Swiss-Prot: sp|O26153|IPK_METTH Isopentenyl phosphate kinase; TrEMBL-Plants: tr|A0A0B2P2T3|A0A0B2P2T3_GLYSO Uncharacterized protein; Found in the gene: LotjaGi2g1v0299100 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04241 | CDD | 1 | 33.33 |