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IPR024960

Source: InterPro

Description

IPR024960 is a Phosphatidyl-N-methylethanolamine/Phosphatidylethanolamine N-methyltransferase.

<p>This family includes yeast phosphatidyl-N-methylethanolamine N-methyltransferase CHO1/OPI3 [[cite:PUB00087310]] and vertebrates phosphatidylethanolamine N-methyltransferases [[cite:PUB00009897], [cite:PUB00057255]]. In yeast, this enzyme catalyzes the second two steps of the methylation pathway of phosphatidylcholine (PC) biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to PC. In vertebrates, it catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to PC.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006656
Biological process Phosphatidylcholine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
Subterm of
GO:0008757
Molecular function S-adenosylmethionine-dependent methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj0g3v0319119.1
– Phospholipid N-methyltransferase [Medicago truncatula] gi|357467929|ref|XP_003604249.1|
Domains
2
Lj0g3v0319129.1
– Phospholipid N-methyltransferase [Medicago truncatula] gi|357467929|ref|XP_003604249.1|
Domains
6
LotjaGi3g1v0349500.1
– N-methyltransferase; TAIR: AT1G80860.1 phospholipid N-methyltransferase; Swiss-Prot: sp|Q9SAH5|PLMT_ARATH Phosphatidyl-N-methylethanolamine N-methyltransferase; TrEMBL-Plants: tr|A0A1J7HT91|A0A1J7HT91_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0349500
Domains
10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 33.33