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IPR025654 is a Peroxisome biogenesis factor 2/10.
<p>Peroxisome biogenesis factor 2 and 10, also known as peroxin-2/10 are involved in the formation of peroxisomes and matrix protein import. Tey form a retrotranslocation channel together with PEX12, which mediates the export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling [[cite:PUB00057427], [cite:PUB00057428], [cite:PUB00101891]]. Each subunit contributes transmembrane segments that coassemble into an open channel. PEX2 is also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis [[cite:PUB00101917]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: peroxisome biogenesis factor 10-like [Glycine max] gi|356564027|ref|XP_003550258.1| | 18 | ||
| – | PREDICTED: peroxisome biogenesis factor 10-like [Cicer arietinum] gi|502125238|ref|XP_004498856.1| | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |