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IPR025779 is a Methionine S-methyltransferase.
<p>This entry represents the methionine S-methyltransferase ([ec:2.1.1.12]) family, which catalyse the S-methylmethionine (SMM) biosynthesis from adenosyl-L-homocysteine (AdoMet) and methionine [[cite:PUB00058009]]. All flowering plants produce S-methylmethionine (SMM) from Met and have a separate mechanism to convert SMM back to Met. The functions of SMM and the reasons for its interconversion with Met are unknown [[cite:PUB00058008]].</p> <p>Methyltransferases (EC [ec:2.1.1.-]) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00054125]]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM [[cite:PUB00006319]]. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00006319]]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00054125]]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: methionine S-methyltransferase-like [Glycine max] gi|356541838|ref|XP_003539379.1| | 17 | ||
| – | Methionine S-methyltransferase; TAIR: AT5G49810.1 methionine S-methyltransferase; Swiss-Prot: sp|Q9LTB2|MMT1_ARATH Methionine S-methyltransferase; TrEMBL-Plants: tr|I1LT87|I1LT87_SOYBN Methionine S-methyltransferase; Found in the gene: LotjaGi2g1v0261000 | 15 | ||
| – | Methionine S-methyltransferase; TAIR: AT5G49810.1 methionine S-methyltransferase; Swiss-Prot: sp|Q9LTB2|MMT1_ARATH Methionine S-methyltransferase; TrEMBL-Plants: tr|I1LT87|I1LT87_SOYBN Methionine S-methyltransferase; Found in the gene: LotjaGi2g1v0261000 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02440 | CDD | 1 | 33.33 |