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IPR026151 is a Maspardin.
<p>The maspardin protein (Mast syndrome, spastic paraplegia, autosomal recessive with dementia) is a member of the AB hydrolase superfamily that has been shown to localise to intracellular endosomal/trans-Golgi transportation vesicles and may function in protein transport and sorting [[cite:PUB00060125]]. The protein has also been shown to interact with CD4, and may play a role as a negative regulatory factor in CD4-dependent T-cell activation [[cite:PUB00060125]]. Although sequence alignments show maspardin to be a member of the AB hydrolase superfamily, they also show it to lack the nucleophile-acid-histidine triad required for catalytic function, suggesting that maspardin is unlikely to function as an enzyme [[cite:PUB00060126]]. Defects in the maspardin gene are the cause of spastic paraplegia autosomal recessive type 21 (SPG21), also known as Mast syndrome. Mast syndrome is a neurodegenerative disorder characterised by a slow, gradual, progressive weakness and spasticity of the lower limbs [[cite:PUB00060126]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: maspardin-like [Cicer arietinum] gi|502175950|ref|XP_004515771.1| | 9 | ||
| – | PREDICTED: maspardin-like [Glycine max] gi|356514127|ref|XP_003525758.1| | 4 | ||
| – | Maspardin; TAIR: AT4G12230.1 alpha/beta-Hydrolases superfamily protein; Swiss-Prot: sp|Q8MJJ1|SPG21_BOVIN Maspardin; TrEMBL-Plants: tr|I3SSQ0|I3SSQ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0215300 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |