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IPR026243 is a HAUS augmin-like complex subunit 1.
<p>Assembly of a robust microtubule-based mitotic spindle is essential for accurate segregation of chromosomes to progeny [[cite:PUB00056754]]. Spindle assembly relies on the concerted action of centrosomes, spindle microtubules, molecular motors and non-motor spindle proteins [[cite:PUB00056754]]. A number of novel regulators of spindle assembly have been identified: one of these is HAUS, an 8-subunit protein complex that shares similarity with Drosophila Augmin [[cite:PUB00056754], [cite:PUB00056753]]. Plants also have a augmin complex consisting of eight subunits. Subunits AUG1 to AUG6 can be aligned with the human HAUS1 to HAUS6 proteins [[cite:PUB00068102]].</p> <p>HAUS localises to interphase centrosomes and to mitotic spindle micro- tubules; its disruption induces microtubule-dependent fragmentation of centrosomes, and an increase in centrosome size. HAUS disruption results in the destabilisation of kinetochore microtubules and eventual formation of multipolar spindles. Such severe mitotic defects are alleviated by co-depletion of NuMA, indicating that both factors regulate opposing activities. HAUS disruption alters NuMA localisation, suggesting that mis-localised NuMA activity contributes to the observed spindle and centrosome defects. The Augmin complex (HAUS) is thus a critical, evolutionarily conserved multi-subunit protein complex that regulates centrosome and spindle integrity [[cite:PUB00056754]].</p> <p>The HAUS (Homologous to AUgmin Subunits) individual subunits have been designated HAUS1 to HAUS8 [[cite:PUB00056754]]. HAUS augmin-like complex subunit 1 (also known as enhancer of invasion-cluster, HEI-C [[cite:PUB00056753]], and coiled-coil domain-containing protein 5) is a coiled-coil protein required for passage through mitosis [[cite:PUB00060266]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Spindle assembly | The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. | ||
| Cellular component | HAUS complex | A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | HAUS augmin-like complex subunit 1; TAIR: AT2G41350.1 HAUS augmin-like complex subunit; Swiss-Prot: sp|F4IK01|AUG1_ARATH AUGMIN subunit 1; TrEMBL-Plants: tr|A0A1J7IVC7|A0A1J7IVC7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0192800 | 3 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR31570 | PANTHER | 1 | 100.00 |