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IPR027495 is a Thiamine thiazole synthase.
<p>This entry represents the thiamine thiazole synthase, which is involved in biosynthesis of the thiamine precursor thiazole in fungi and in chloroplasts. It catalyses the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. It may have additional roles in adaptation to various stress conditions and in DNA damage tolerance [[cite:PUB00064744], [cite:PUB00064745]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Thiamine biosynthetic process | The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: thiamine thiazole synthase, chloroplastic-like [Cicer arietinum] gi|502140800|ref|XP_004504342.1| | 12 | ||
| – | PREDICTED: thiamine thiazole synthase 2, chloroplastic-like [Cicer arietinum] gi|502119905|ref|XP_004496776.1| | 16 | ||
| – | Thiamine thiazole synthase, chloroplastic; TAIR: AT5G54770.1 thiazole biosynthetic enzyme, chloroplast (ARA6) (THI1) (THI4); Swiss-Prot: sp|F6H7K5|THI42_VITVI Thiamine thiazole synthase 2, chloroplastic; TrEMBL-Plants: tr|I3T7E0|I3T7E0_LOTJA Thiamine thiazole synthase, chloroplastic; Found in the gene: LotjaGi3g1v0149500 | 12 | ||
| – | Thiamine thiazole synthase, chloroplastic; TAIR: AT5G54770.1 thiazole biosynthetic enzyme, chloroplast (ARA6) (THI1) (THI4); Swiss-Prot: sp|F6H7K5|THI42_VITVI Thiamine thiazole synthase 2, chloroplastic; TrEMBL-Plants: tr|I3TAU0|I3TAU0_LOTJA Thiamine thiazole synthase, chloroplastic; Found in the gene: LotjaGi5g1v0317600 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00292 | TIGRFAM | 1 | 25.00 |