Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR028144 is a Cysteine-rich transmembrane CYSTM domain.
<p>Proteins containing CYSTM domain are short cysteine-rich membrane proteins that most probably dimerise together to form a transmembrane sulfhydryl-lined pore. The CYSTM domain is always present at the extreme -terminus of the protein in which it is present. Furthermore, like the yeast prototypes, the majority of the proteins also possess a proline/glutamine-rich segment upstream of the CYSTM domain that is likely to form a polar, disordered head in the cytoplasm. The presence of an atypical well-conserved acidic residue at the C-terminal end of the TM helix suggests that this might interact with a positively charged moiety in the lipid head group. Consistently across the eukaryotes, the different versions of the CYSTM domain appear to have roles in stress-response or stress-tolerance, and, more specifically, in resistance to deleterious substances, implying that these might be general functions of the whole family [[cite:PUB00067579], [cite:PUB00100192]]. This entry also includes Protein CADMIUM TOLERANCE 1-5 from rice, which confers resistance to heavy metal ions such as cadmium and copper [[cite:PUB00100384], [cite:PUB00100385]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: CYSTM1 family protein A-like [Cicer arietinum] gi|502108190|ref|XP_004493409.1| | 3 | ||
| – | Uncharacterized protein TCM_000918 [Theobroma cacao] gi|508699959|gb|EOX91855.1| | 4 | ||
| – | PREDICTED: CYSTM1 family protein A-like [Cicer arietinum] gi|502089116|ref|XP_004488823.1| | 5 | ||
| – | PREDICTED: CYSTM1 family protein A-like isoform X3 [Cicer arietinum] gi|502089130|ref|XP_004488826.1| | 5 | ||
| – | Adhesive/proline-rich protein homolog [Arabidopsis thaliana] gi|21618167|gb|AAM67217.1| | 5 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |