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IPR028222

Source: InterPro

Description

IPR028222 is a AP-5 complex subunit zeta-1.

<p>AP-5 complex subunit zeta-1 is a component of the fifth Adaptor-Protein complex (AP-5) [[cite:PUB00067711]]. Adaptor protein (AP) complexes facilitate the trafficking of cargo from one membrane compartment of the cell to another by recruiting other proteins to particular types of vesicles. AP-5 is involved in trafficking proteins from endosomes towards other membranous compartments [[cite:PUB00067709]]. There are genetic links between AP-5 and hereditary spastic paraplegia, a group of human genetic disorders characterised by progressive spasticity in the lower limbs [[cite:PUB00067710]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0044599
Cellular component AP-5 adaptor complex An AP-type membrane coat adaptor complex that in humans consists of beta5, zeta, mu5 and sigma5 subunits and is found associated with membranes in the endosomes; it is not clear whether AP-5 forms clathrin coats in vivo.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj0g3v0175829.1
– PREDICTED: AP-5 complex subunit zeta-1-like isoform X1 [Cicer arietinum] gi|502143745|ref|XP_004505450.1|
Domains
6
LotjaGi3g1v0148300.1
– AP-5 complex subunit zeta-1; TAIR: AT3G15160.1 AP-5 complex subunit zeta-1; Swiss-Prot: sp|Q3U829|AP5Z1_MOUSE AP-5 complex subunit zeta-1; TrEMBL-Plants: tr|I3S8F3|I3S8F3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0148300
Domains
5

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF48371 SUPERFAMILY 1 50.00