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IPR029327 is a HAUS augmin-like complex subunit 4.
<p>HAUS4 is part of the HAUS augmin-like complex, which contributes to mitotic spindle assembly, maintenance of chromosome integrity and completion of cytokinesis [[cite:PUB00056754], [cite:PUB00056753]].</p> <p>Human augmin complex is composed of 8 subunits and interacts with the gamma-tubulin ring complex (gamma-TuRC) in centrosomes [[cite:PUB00056753]]. This interaction affects MT generation during mitosis and is critical for chromosome segregation and cytokinesis in human cells [[cite:PUB00056753]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Spindle assembly | The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. | ||
| Cellular component | HAUS complex | A protein complex that localizes to interphase centrosomes and to mitotic spindle tubules and regulates mitotic spindle assembly and centrosome integrity; in human, the complex consists of eight subunits, some of which are homologous to subunits of the Drosophila Augmin complex. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | HAUS augmin-like complex subunit [Medicago truncatula] gi|357459655|ref|XP_003600108.1| | 6 | ||
| – | HAUS augmin-like complex subunit [Medicago truncatula] gi|357459655|ref|XP_003600108.1| | 6 | ||
| – | HAUS augmin-like complex subunit 4; TAIR: AT1G50710.1 HAUS augmin-like complex subunit; Swiss-Prot: sp|Q8GYM3|AUG4_ARATH AUGMIN subunit 4; TrEMBL-Plants: tr|A0A1J7IER7|A0A1J7IER7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0159200 | 4 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR16219 | PANTHER | 1 | 33.33 |