Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR030616 is a Aurora kinase-like.
<p>Aurora kinase was discovered by Glover and colleagues in a screen for genes required to maintain the centrosome cycle in Drosophila [[cite:PUB00073353]]. Its yeast homologue Ipl1 (also known as spindle assembly checkpoint kinase) was found to regulate chromosome segregation [[cite:PUB00073357]]. Subsequently, three mammal Aurora kinases, Aurora A, B and C, have been identified.</p> <p>They are highly conserved serine/threonine kinases that regulate chromosomal alignment and segregation during mitosis and meiosis [[cite:PUB00073360]]. They all contain a protein kinase domain and a destruction box (D-box) recognised by the multi-subunit E3-ubiquitin ligase anaphase promoting complex/cyclosome (APC/C), which mediates their proteasomal degradation. However, their N-terminal domains share little sequence identity and confer unique protein-protein interaction abilities among the Aurora kinases [[cite:PUB00073329]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: serine/threonine-protein kinase Aurora-3 [Vitis vinifera] gi|225453778|ref|XP_002270462.1| | 7 | ||
| – | PREDICTED: serine/threonine-protein kinase Aurora-3 [Vitis vinifera] gi|225453778|ref|XP_002270462.1| | 10 | ||
| – | PREDICTED: serine/threonine-protein kinase Aurora-1-like isoform X1 [Cicer arietinum] gi|502131750|ref|XP_004501089.1| | 17 | ||
| – | PREDICTED: serine/threonine-protein kinase Aurora-3-like [Glycine max] gi|356545969|ref|XP_003541405.1| | 14 | ||
| – | PREDICTED: serine/threonine-protein kinase Aurora-3-like [Glycine max] gi|356545969|ref|XP_003541405.1| | 18 | ||
| – | PREDICTED: serine/threonine-protein kinase Aurora-3-like [Glycine max] gi|356545969|ref|XP_003541405.1| | 20 | ||
| – | Protein kinase; TAIR: AT2G25880.1 ataurora2; Swiss-Prot: sp|Q9M077|AUR1_ARATH Serine/threonine-protein kinase Aurora-1; TrEMBL-Plants: tr|A0A072V349|A0A072V349_MEDTR Serine/Threonine-kinase aurora-like protein; Found in the gene: LotjaGi1g1v0409900 | 22 | ||
| – | Kinase family protein; TAIR: AT2G45490.1 ataurora3; Swiss-Prot: sp|O64629|AUR3_ARATH Serine/threonine-protein kinase Aurora-3; TrEMBL-Plants: tr|I1LZ26|I1LZ26_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0473500_LC | 14 | ||
| – | Kinase family protein; TAIR: AT2G45490.1 ataurora3; Swiss-Prot: sp|O64629|AUR3_ARATH Serine/threonine-protein kinase Aurora-3; TrEMBL-Plants: tr|I1LZ26|I1LZ26_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0076800 | 18 | ||
| – | Kinase family protein; TAIR: AT2G45490.1 ataurora3; Swiss-Prot: sp|O64629|AUR3_ARATH Serine/threonine-protein kinase Aurora-3; TrEMBL-Plants: tr|A0A0R0KN90|A0A0R0KN90_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0076800 | 15 | ||
| – | Kinase family protein; TAIR: AT2G45490.1 ataurora3; Swiss-Prot: sp|O64629|AUR3_ARATH Serine/threonine-protein kinase Aurora-3; TrEMBL-Plants: tr|I1LZ26|I1LZ26_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0076800 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd14007 | CDD | 1 | 9.09 |