Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR032839 is a Rab3-GAP regulatory subunit, N-terminal.
<p>This family includes the N terminus of the Rab3 GTPase-activating protein (GAP) non-catalytic subunit.</p> <p>Small G proteins of the Rab family are regulators of intracellular vesicle traffic. Their rate of GTP hydrolysis is enhanced by specific GTPase-activating proteins (GAPs) that switch G proteins to their inactive form [[cite:PUB00060687]]. Rab3GAP1 (catalytic subunit) has been shown to form a heterodimeric complex with Rab3GAP2 (the regulatory subunit), and this complex acts as a guanosine nucleotide exchange factor for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3GAP complex may participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters [[cite:PUB00060112], [cite:PUB00060113]]. It also activates Rab18 and promotes autolysosome maturation through the Vps34 Complex I [[cite:PUB00098930]].</p> <p>Mutations in the Rab3GAP1/2 gene cause Warburg micro syndrome (WMS), a hereditary autosomal neuromuscular disorder [[cite:PUB00060114]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: rab3 GTPase-activating protein non-catalytic subunit-like [Glycine max] gi|356514563|ref|XP_003525975.1| | 4 | ||
| – | PREDICTED: rab3 GTPase-activating protein non-catalytic subunit-like [Cicer arietinum] gi|502177437|ref|XP_004516083.1| | 4 | ||
| – | PREDICTED: rab3 GTPase-activating protein non-catalytic subunit-like [Cicer arietinum] gi|502177437|ref|XP_004516083.1| | 7 | ||
| – | PREDICTED: rab3 GTPase-activating protein non-catalytic subunit-like [Cicer arietinum] gi|502177437|ref|XP_004516083.1| | 5 | ||
| – | PREDICTED: rab3 GTPase-activating protein non-catalytic subunit-like [Cicer arietinum] gi|502177437|ref|XP_004516083.1| | 4 | ||
| – | Rab3 GTPase-activating protein non-catalytic subunit; TAIR: AT3G14910.1 Rab3 GTPase-activating protein non-catalytic subunit; Swiss-Prot: sp|Q9H2M9|RBGPR_HUMAN Rab3 GTPase-activating protein non-catalytic subunit; TrEMBL-Plants: tr|A0A072TPX7|A0A072TPX7_MEDTR Rab3 GTPase-activating protein non-catalytic subunit; Found in the gene: LotjaGi3g1v0041500 | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |