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IPR032843

Source: InterPro

Description

IPR032843 is a Cleavage inducing molecular chaperone, Jiv.

<p>This entry represents Jiv (J-domain protein interacting with viral protein), a domain found in the DnaJ protein from eukaryotes [[cite:PUB00072577]]. It can also be found in the N-terminal region of the pestivirus viral polypeptide. The viral protein interacts stably with non structural (NS) protein NS2, causing a conformational change in NS2-NS3 and stimulates NS2-NS3 cleavage in trans. Cleavage of NS2-NS3 increases cytopathogenicity and consequently aids viral replication. Jiv therefore acts as a regulating cofactor for NS2 auto-protease. The efficient release of NS3 from the viral polypeptide by Jiv is considered crucial to the pestivirus cytopathogenicity [[cite:PUB00076844]]. In eukaryotes, it usually lies 40 residues downstream of DnaJ domain ([interpro:IPR001623]). However, the function of this domain in eukaryotes is still unknown.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
Lj0g3v0205899.1
– PREDICTED: dnaJ homolog subfamily C member 14-like [Glycine max] gi|356555977|ref|XP_003546304.1|
Domains
20
Lj3g3v0977770.1
– Chaperone protein dnaJ [Medicago truncatula] gi|357451459|ref|XP_003596006.1|
Domains
18
Lj3g3v0977770.2
– Chaperone protein dnaJ [Medicago truncatula] gi|357451459|ref|XP_003596006.1|
Domains
10
LotjaGi3g1v0142600.1
– Chaperone protein dnaJ; TAIR: AT1G79030.1 Chaperone DnaJ-domain superfamily protein; Swiss-Prot: sp|Q921R4|DJC14_MOUSE DnaJ homolog subfamily C member 14; TrEMBL-Plants: tr|A0A151SW43|A0A151SW43_CAJCA DnaJ isogeny subfamily C member 14; Found in the gene: LotjaGi3g1v0142600
Domains
19
LotjaGi3g1v0142600.2
– Chaperone protein dnaJ; TAIR: AT1G79030.1 Chaperone DnaJ-domain superfamily protein; Swiss-Prot: sp|Q95J56|DJC14_BOVIN DnaJ homolog subfamily C member 14; TrEMBL-Plants: tr|A0A151SW43|A0A151SW43_CAJCA DnaJ isogeny subfamily C member 14; Found in the gene: LotjaGi3g1v0142600
Domains
19
LotjaGi6g1v0261600.1
– Chaperone protein DnaJ; TAIR: AT5G49580.1 Chaperone DnaJ-domain superfamily protein; Swiss-Prot: sp|Q95J56|DJC14_BOVIN DnaJ homolog subfamily C member 14; TrEMBL-Plants: tr|A0A0B2PYT5|A0A0B2PYT5_GLYSO DnaJ like subfamily C member 14; Found in the gene: LotjaGi6g1v0261600
Domains
21

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 16.67