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IPR033872 is a Non-specific lipid-transfer protein type 2.
<p>Plant nsLTPs are small, soluble proteins that facilitate the transfer of fatty acids, phospholipids, glycolipids, and steroids between membranes [[cite:PUB00081503]]. In addition to lipid transport and assembly, nsLTPs also play a key role in the defense of plants against pathogens [[cite:PUB00081502]]. There are two closely-related types of nsLTPs, types 1 and 2, which differ in protein sequence, molecular weight, and biological properties. nsLTPs contain an internal hydrophobic cavity, which serves as the binding site for lipids. Structure studies of rice nsLTPs show that the plasticity of the hydrophobic cavity is an important factor in ligand binding [[cite:PUB00026937]]. nsLTP2s possess a more flexible central hydrophobic cavity, resulting in increased lipid transfer activity [[cite:PUB00081510]]. The flexibility of the sLTP2 cavity allows its binding to rigid sterol molecules, whereas nsLTP1 cannot bind sterols despite its larger cavity size. The resulting nsLTP2/sterol complexes may bind to receptors that trigger defense responses [[cite:PUB00081502]]. The nsLTP2 of Brassica rapa has been identified as a potent allergen [[cite:PUB00081509], [cite:PUB00081504]].</p> <p>This entry represents the non-specific lipid-transfer protein type 2 (nsLTP2) family.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Lipid transport | The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable non-specific lipid-transfer protein AKCS9-like [Glycine max] gi|356573851|ref|XP_003555069.1| | 17 | ||
| – | PREDICTED: probable non-specific lipid-transfer protein AKCS9-like [Glycine max] gi|356520615|ref|XP_003528957.1| | 16 | ||
| – | Lipid transfer protein; TAIR: AT3G18280.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein; Swiss-Prot: sp|P82353|NLTP2_PRUAR Non-specific lipid-transfer protein 2; TrEMBL-Plants: tr|I3SBE1|I3SBE1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0203100 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01959 | CDD | 1 | 33.33 |