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IPR033940 is a 3-isopropylmalate dehydratase, swivel domain.
<p>3-isopropylmalate dehydratase (or isopropylmalate isomerase; IPMI; [ec:4.2.1.33]) catalyses the stereo-specific isomerisation of 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. This enzyme performs the second step in the biosynthesis of leucine, and is present in most prokaryotes and many fungal species. The prokaryotic enzyme is a heterodimer composed of a large (LeuC) and small (LeuD) subunit, while the fungal form is a monomeric enzyme. Both forms of isopropylmalate are related and are part of the larger aconitase family [[cite:PUB00005471]].</p> <p>This entry represents the aconitase-like swivel domain of 3-isopropylmalate dehydratase small subunit, which is believed to undergo swivelling conformational change in the enzyme mechanism.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | 3-isopropylmalate dehydratase small subunit; TAIR: AT2G43090.1 Aconitase/3-isopropylmalate dehydratase protein; Swiss-Prot: sp|Q9ZW85|LEUD3_ARATH 3-isopropylmalate dehydratase small subunit 3; TrEMBL-Plants: tr|I3SAF2|I3SAF2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0358800 | 12 | ||
| – | 3-isopropylmalate dehydratase small subunit; TAIR: AT2G43090.1 Aconitase/3-isopropylmalate dehydratase protein; Swiss-Prot: sp|Q9ZW85|LEUD3_ARATH 3-isopropylmalate dehydratase small subunit 3; TrEMBL-Plants: tr|I3SAF2|I3SAF2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0358800 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |