Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR036320 is a Glycosyl transferase family 3, N-terminal domain superfamily.
<p>The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates ([ec:2.4.1.-]) and related proteins into distinct sequence based families has been described [[cite:PUB00009409]]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.</p> <p>This N-terminal domain is found in various family 3 glycosyl transferases, including anthranilate phosphoribosyltransferase (TrpD, [ec:2.4.2.18]) [[cite:PUB00097341]] and thymidine phosphorylase ([ec:2.4.2.2]). All these proteins can transfer a phosphorylated ribose substrate. Thymidine phosphorylase catalyses the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate [[cite:PUB00097340]]. This enzyme regulates the availability of thymidine and is therefore essential to nucleic acid metabolism. It promotes metastasis in Hepatocellular carcinoma (HCC) and may serve as a marker of poor prognosis in HCC, being a potential target for the treatment of HCC [[cite:PUB00097340]]. Thymidine phosphorylase is also involved platelet activation and thrombosis leading to the development of cardiovascular diseases, thus, it has been suggested as a new target for cardiovascular disease treatment [[cite:PUB00097342]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Anthranilate phosphoribosyltransferase; TAIR: AT5G17990.1 tryptophan biosynthesis 1; Swiss-Prot: sp|Q02166|TRPD_ARATH Anthranilate phosphoribosyltransferase, chloroplastic; TrEMBL-Plants: tr|I3SIF7|I3SIF7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0178700 | 20 | ||
| – | Anthranilate phosphoribosyltransferase; TAIR: AT1G70570.1 anthranilate phosphoribosyltransferase; Swiss-Prot: sp|O66576|TRPD_AQUAE Anthranilate phosphoribosyltransferase; TrEMBL-Plants: tr|A0A0S3R273|A0A0S3R273_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0157300 | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF52418 | SUPERFAMILY | 1 | 50.00 |