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IPR036537 is a Adaptor protein Cbl, N-terminal domain superfamily.
<p>Cbl (Casitas B-lineage lymphoma) is an adaptor protein that functions as a negative regulator of many signalling pathways that start from receptors at the cell surface.</p> <p>The N-terminal region of Cbl contains a Cbl-type phosphotyrosine-binding (Cbl-PTB) domain, which is composed of three evolutionarily conserved domains: an N-terminal four-helix bundle (4H) domain, an EF hand-like calcium-binding domain, and a divergent SH2-like domain. The calcium-bound EF-hand wedges between the 4H and SH2 domains, and roughly determines their relative orientation. The Cbl-PTB domain has also been named Cbl N-terminal (Cbl-N) or tyrosine kinase binding (TKB) domain [[cite:PUB00019259], [cite:PUB00055526]].</p> <p>The N-terminal 4H domain contains four long α-helices. The C and D helices in this domain pack against the adjacent EF-hand-like domain, and a highly conserved loop connecting the A and B helices contacts the SH2-like domain. The EF-hand motif is similar to classical EF-hand proteins. The SH2-like domain retains the general helix-sheet-helix architecture of the SH2 fold, but lacks the secondary β-sheet, comprising β-strands D', E and F, and also a prominent BG loop [[cite:PUB00019259]].</p> <p>This entry represents the N-terminal four-helical bundle domain superfamily. This domain can also be found in the N terminus of mammalian MLKL, a pseudokinase essential for TNF-alpha-induced necroptosis [[cite:PUB00088134]]. The four-helical bundle (NB) domain of MLK is involved in oligomerization to facilitate plasma membrane targeting through the low-affinity binding of NB to phosphorylated inositol polar head groups of phosphatidylinositol phosphate (PIP) phospholipids [[cite:PUB00088133], [cite:PUB00088135]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Cell surface receptor signaling pathway | A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | U-box domain-containing protein; TAIR: AT3G46510.1 plant U-box 13; Swiss-Prot: sp|Q9SNC6|PUB13_ARATH U-box domain-containing protein 13; TrEMBL-Plants: tr|A0A072UM21|A0A072UM21_MEDTR Armadillo/beta-catenin repeat protein; Found in the gene: LotjaGi2g1v0372400 | 24 | ||
| – | Protein MID1-COMPLEMENTING ACTIVITY 1; TAIR: AT4G35920.1 PLAC8 family protein; Swiss-Prot: sp|Q8L7E9|MCAC1_ARATH Protein MID1-COMPLEMENTING ACTIVITY 1; TrEMBL-Plants: tr|I1LI39|I1LI39_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0379100 | 11 | ||
| – | Protein MID1-COMPLEMENTING ACTIVITY 1; TAIR: AT4G35920.1 PLAC8 family protein; Swiss-Prot: sp|Q8L7E9|MCAC1_ARATH Protein MID1-COMPLEMENTING ACTIVITY 1; TrEMBL-Plants: tr|A0A151THS6|A0A151THS6_CAJCA Uncharacterized protein family; Found in the gene: LotjaGi2g1v0379100 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 33.33 |