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IPR039188 is a ATPase family AAA domain-containing protein 3.
<p>This entry represents ATAD3 and its homologues, including ATAD3A/B/C from humans. They play an important role in mitochondrial network organization [[cite:PUB00089260]]. ATAD3A is involved in mitochondrial-mediated antiviral innate immunity [[cite:PUB00102746]]. ATAD3 contains two N-terminal coiled-coil domains, a central trans-membrane segment and a conserved C-terminal ATPase domain of the AAA+-type with an ATP-binding (Walker A motif) and a catalytic ATPase domain (Walker B motif) [[cite:PUB00089261]].</p> <p>ATAD-3 is necessary for Caenorhabditis elegans larval development and is essential for the progression of the first steps of post-implantation development in mice [[cite:PUB00089260], [cite:PUB00089262]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. | ||
| Biological process | Mitochondrion organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | ATPase family AAA domain-containing protein 3; TAIR: AT2G18330.1 AAA-type ATPase family protein; Swiss-Prot: sp|Q6PAX2|ATD3B_XENLA ATPase family AAA domain-containing protein 3-B; TrEMBL-Plants: tr|V7CJ53|V7CJ53_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0389400 | 23 | ||
| – | ATPase family AAA domain-containing protein 3; TAIR: AT3G03060.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q6NVR9|ATAD3_XENTR ATPase family AAA domain-containing protein 3; TrEMBL-Plants: tr|A0A1J7HGN5|A0A1J7HGN5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0542900 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |