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IPR040227

Source: InterPro

Description

IPR040227 is a Nibrin-related.

<p>Nibrin (also known as Nbs1 or p95) plays an important role in the DNA damage response (DDR) and DNA repair. It is part of the nuclear MRN complex, which consists of Mre11, Rad50, and Nbs1, and is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis [[cite:PUB00062775], [cite:PUB00073636], [cite:PUB00073637], [cite:PUB00073639], [cite:PUB00073638], [cite:PUB00073635]]. Mutations in the NBN gene coding for nibrin cause the Nijmegen Breakage Syndrome (NBS), a rare autosomal recessive disorder characterised by genomic instability and increased risk of haematopoietic malignancies [[cite:PUB00073633], [cite:PUB00073634]].</p> <p>NBS1 homologues from plants are also involved in DNA repair and recombination [[cite:PUB00090721]]. In S. pombe, Nbs1 is required for DNA damage repair and S-phase DNA damage checkpoint [[cite:PUB00091076], [cite:PUB00091077]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006302
Biological process Double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
Subterm of
GO:0007095
Biological process Mitotic G2 DNA damage checkpoint A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.
Subterm of
GO:0030870
Cellular component Mre11 complex Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0102800.1
– Nijmegen breakage syndrome 1 protein; TAIR: AT3G02680.1 nijmegen breakage syndrome 1; Swiss-Prot: sp|Q0H8D7|NBS1_ARATH Nijmegen breakage syndrome 1 protein; TrEMBL-Plants: tr|G7K5Y3|G7K5Y3_MEDTR NBS1-like protein; Found in the gene: LotjaGi1g1v0102800
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 100.00