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IPR040371 is a Regulator of MON1-CCZ1 complex.
<p>RMC1 is a componement of the the CCZ1-MON1 complex, which functions as a guanine exchange factor (GEF) for RAB7 during endocytic and autophagic flux to the lysosome. It positively regulates CCZ1-MON1 function that is necessary for endosomal/autophagic flux and efficient RAB7 localization on CD63-positive vesicle membranes [[cite:PUB00090867]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Regulation of autophagy | Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. | ||
| Cellular component | Mon1-Ccz1 complex | A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Colon cancer-associated Mic1-like protein; TAIR: AT3G12010.1 C18orf8; Swiss-Prot: sp|Q96DM3|MIC1_HUMAN Uncharacterized protein C18orf8; TrEMBL-Plants: tr|I1N9B7|I1N9B7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0278100 | 5 | ||
| – | Colon cancer-associated Mic1-like protein; TAIR: AT3G12010.1 C18orf8; Swiss-Prot: sp|Q96DM3|MIC1_HUMAN Uncharacterized protein C18orf8; TrEMBL-Plants: tr|I1N9B7|I1N9B7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0278100 | 5 | ||
| – | Colon cancer-associated Mic1-like protein; TAIR: AT3G12010.1 C18orf8; Swiss-Prot: sp|Q96DM3|MIC1_HUMAN Uncharacterized protein C18orf8; TrEMBL-Plants: tr|I1N9B7|I1N9B7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0278100 | 5 | ||
| – | Colon cancer-associated Mic1-like protein; TAIR: AT3G12010.1 C18orf8; Swiss-Prot: sp|Q96DM3|MIC1_HUMAN Uncharacterized protein C18orf8; TrEMBL-Plants: tr|I1N9B7|I1N9B7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0278100 | 5 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |