Description

IPR042031 is a SKA1 microtubule binding domain superfamily.

<p>This superfamily corresponds to the microtubule binding domain (MBD) in SKA1, spindle and kinetochore associated protein 1. Its structure is a variation of the winged helix domain which, in addition of the three helix-bundle and anti-parallel β-sheets found in canonical winged-helix domains, it contains an extended helix (αB) as part of three helix bundle and an additional helix (αC) inserted between αB and βA [[cite:PUB00077598]].</p> <p>Spindle and kinetochore-associated protein 1 (SKA1, also known as SKA complex subunit 1) is a component of the SKA1 complex (consists of Ska1, Ska2, and Ska3/Rama1), a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation [[cite:PUB00061771]]. It is required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint [[cite:PUB00061805]]. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerisation-coupled manner. SKA1 contains a microtubule-binding domain that interacts with tubulins using multiple contact sites that allow the Ska complex to bind microtubules in multiple modes [[cite:PUB00077600]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 2

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: