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Field | Value |
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Namespace | Cellular component |
Short description | Transcription factor TFIIIC complex |
Full defintion | A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions. |
Subterm of |
The relationship of GO:0000127 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0000127, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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GOC | vw |
PMID | A role for TFIIIC transcription factor complex in genome organization. Cell. 2006 Jun 2; 125 (5): 859–72.PMID: 16751097 Eukaryotic genome complexity necessitates boundary and insulator elements to partition genomic content into distinct domains. We show that inverted repeat (IR) boundary elements flanking the fission yeast mating-type heterochromatin domain contain B-box sequences, which prevent heterochromatin from spreading into neighboring euchromatic regions by recruiting transcription factor TFIIIC complex without RNA polymerase III (Pol III). Genome-wide analysis reveals TFIIIC with Pol III at all tRNA genes, many of which cluster at pericentromeric heterochromatin domain boundaries. However, a single tRNA(phe) gene with modest TFIIIC enrichment is insufficient to serve as boundary and requires RNAi-associated element to restrain heterochromatin spreading. Remarkably, we found TFIIIC localization without Pol III at many sites located between divergent promoters. These sites appear to act as chromosome-organizing clamps by tethering distant loci to the nuclear periphery, at which TFIIIC is concentrated into several distinct bodies. Our analyses uncover a general genome organization mechanism involving conserved TFIIIC complex. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
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– | General transcription factor 3C polypeptide 5; TAIR: AT3G49410.1 Transcription factor IIIC, subunit 5; Swiss-Prot: sp|Q9Y5Q8|TF3C5_HUMAN General transcription factor 3C polypeptide 5; TrEMBL-Plants: tr|A0A0B2SC65|A0A0B2SC65_GLYSO General transcription factor 3C polypeptide 5; Found in the gene: LotjaGi2g1v0088000 | 2 | ||
– | General transcription factor 3C polypeptide 5; TAIR: AT3G49410.1 Transcription factor IIIC, subunit 5; Swiss-Prot: sp|Q9Y5Q8|TF3C5_HUMAN General transcription factor 3C polypeptide 5; TrEMBL-Plants: tr|I1LI80|I1LI80_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0357200 | 2 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
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Biological process | Transcription initiation from RNA polymerase III promoter | 1 | 50.00 |