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Field | Value |
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Namespace | Cellular component |
Short description | ESCRT I complex |
Full defintion | An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes. |
Subterm of |
The relationship of GO:0000813 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0000813, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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GOC | rb |
PMID | Vps27 recruits ESCRT machinery to endosomes during MVB sorting. J Cell Biol. 2003 Aug 4; 162 (3): 413–23.PMID: 12900393 Down-regulation (degradation) of cell surface proteins within the lysosomal lumen depends on the function of the multivesicular body (MVB) sorting pathway. The function of this pathway requires the class E vacuolar protein sorting (Vps) proteins. Of the class E Vps proteins, both the ESCRT-I complex (composed of the class E proteins Vps23, 28, and 37) and Vps27 (mammalian hepatocyte receptor tyrosine kinase substrate, Hrs) have been shown to interact with ubiquitin, a signal for entry into the MVB pathway. We demonstrate that activation of the MVB sorting reaction is dictated largely through interactions between Vps27 and the endosomally enriched lipid species phosphatidylinositol 3-phosphate via the FYVE domain (Fab1, YGL023, Vps27, and EEA1) of Vps27. ESCRT-I then physically binds to Vps27 on endosomal membranes via a domain within the COOH terminus of Vps27. A peptide sequence in this domain, PTVP, is involved in the function of Vps27 in the MVB pathway, the efficient endosomal recruitment of ESCRT-I, and is related to a motif in HIV-1 Gag protein that is capable of interacting with Tsg101, the mammalian homologue of Vps23. We propose that compartmental specificity for the MVB sorting reaction is the result of interactions of Vps27 with phosphatidylinositol 3-phosphate and ubiquitin. Vps27 subsequently recruits/activates ESCRT-I on endosomes, thereby facilitating sorting of ubiquitinated MVB cargoes. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | Vacuolar protein sorting-associated protein-like protein [Medicago truncatula] gi|357475863|ref|XP_003608217.1| | 2 | ||
– | Proline-rich cell wall-like protein; TAIR: AT5G53330.1 Ubiquitin-associated/translation elongation factor EF1B protein; Swiss-Prot: sp|Q9NZ09|UBAP1_HUMAN Ubiquitin-associated protein 1; TrEMBL-Plants: tr|I3SQZ2|I3SQZ2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0277000 | 3 | ||
– | Vacuolar protein-sorting-associated protein 37 like 2; TAIR: AT2G36680.1 Modifier of rudimentary (Mod(r)) protein; Swiss-Prot: sp|Q3EBL9|VP372_ARATH Vacuolar protein-sorting-associated protein 37 homolog 2; TrEMBL-Plants: tr|I3T1W6|I3T1W6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0683400 | 2 | ||
– | Vacuolar sorting-associated protein 28-like protein; TAIR: AT4G05000.1 Vacuolar protein sorting-associated protein VPS28 family protein; Swiss-Prot: sp|Q9S9T7|VP282_ARATH Vacuolar protein sorting-associated protein 28 homolog 2; TrEMBL-Plants: tr|G7JRS3|G7JRS3_MEDTR Vacuolar protein sorting-associated protein VPS28, putative; Found in the gene: LotjaGi4g1v0050200 | 2 | ||
– | Vacuolar sorting-associated protein 28-like protein; TAIR: AT4G05000.1 Vacuolar protein sorting-associated protein VPS28 family protein; Swiss-Prot: sp|Q9S9T7|VP282_ARATH Vacuolar protein sorting-associated protein 28 homolog 2; TrEMBL-Plants: tr|G7JRS3|G7JRS3_MEDTR Vacuolar protein sorting-associated protein VPS28, putative; Found in the gene: LotjaGi4g1v0050200 | 2 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Biological process | Endosome transport via multivesicular body sorting pathway | 1 | 20.00 |