Gene Ontology — View

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GO:0004001

Overview

Field	Value
Namespace	Molecular function
Short description	Adenosine kinase activity
Full defintion	Catalysis of the reaction: ATP + adenosine = ADP + AMP.
Subterm of	GO:0016773 GO:0019206

Relationships

The relationship of GO:0004001 with other GO terms.

Relationship type	GO terms
Is a	GO:0016773 GO:0019206
Regulates	n.a.
Part of	n.a.
Positively regulates	n.a.
Negatively regulates	n.a.

Ancestor tree

A force layout showing the ancestor tree for GO:0004001, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field	Value
EC	2.7.1.20
PMID	Role of adenosine kinase in Saccharomyces cerevisiae: identification of the ADO1 gene and study of the mutant phenotypes.Lecoq K, Belloc I, Desgranges C, Daignan-Fornier B Yeast. 2001 Mar 15; 18 (4): 335–42.PMID: 11223943 Sequencing of the Saccharomyces cerevisiae genome revealed an open reading frame (YJR105w) encoding a putative protein highly similar to adenosine kinases from other species. Disruption of this gene (renamed ADO1) affected utilization of S-adenosyl methionine (AdoMet) as a purine source and resulted in a severe reduction of adenosine kinase activity in crude extracts. Furthermore, knock-out of ADO1 led to adenosine excretion in the medium and resistance to the toxic adenosine analogue cordycepin. From these data we conclude that ADO1 encodes yeast adenosine kinase. We also show that ADO1 does not play a major role in adenine utilization in yeast and we propose that the physiological role of adenosine kinase in S. cerevisiae could primarily be to recycle adenosine produced by the methyl cycle.

Field

Value

2.7.1.20

PMID

Role of adenosine kinase in Saccharomyces cerevisiae: identification of the ADO1 gene and study of the mutant phenotypes.Lecoq K, Belloc I, Desgranges C, Daignan-Fornier B
Yeast. 2001 Mar 15; 18 (4): 335–42.PMID: 11223943

Sequencing of the Saccharomyces cerevisiae genome revealed an open reading frame (YJR105w) encoding a putative protein highly similar to adenosine kinases from other species. Disruption of this gene (renamed ADO1) affected utilization of S-adenosyl methionine (AdoMet) as a purine source and resulted in a severe reduction of adenosine kinase activity in crude extracts. Furthermore, knock-out of ADO1 led to adenosine excretion in the medium and resistance to the toxic adenosine analogue cordycepin. From these data we conclude that ADO1 encodes yeast adenosine kinase. We also show that ADO1 does not play a major role in adenine utilization in yeast and we propose that the physiological role of adenosine kinase in S. cerevisiae could primarily be to recycle adenosine produced by the methyl cycle.

Associated Lotus transcripts 6

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Transcript	Name	Description	GO terms	GO count
Lj5g3v0659730.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	Adenosine kinase [Theobroma cacao] gi\|95116510\|gb\|ABF56168.1\|	GO terms View details of GO:0004001 View details of GO:0006166	2
Lj5g3v0659730.2 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	PREDICTED: adenosine kinase 2-like [Cicer arietinum] gi\|502121977\|ref\|XP_004497518.1\|	GO terms View details of GO:0004001 View details of GO:0006166	2
Lj5g3v0659730.3 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	Adenosine kinase [Medicago truncatula] gi\|357440381\|ref\|XP_003590468.1\|	GO terms View details of GO:0004001 View details of GO:0006166	2
LotjaGi1g1v0689800.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	Adenosine kinase, putative; TAIR: AT5G03300.1 adenosine kinase 2; Swiss-Prot: sp\|Q9LZG0\|ADK2_ARATH Adenosine kinase 2; TrEMBL-Plants: tr\|A0A0B2P3T7\|A0A0B2P3T7_GLYSO Adenosine kinase 2; Found in the gene: LotjaGi1g1v0689800	GO terms View details of GO:0004001 View details of GO:0006166	2
LotjaGi5g1v0080200.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	Adenosine kinase, putative; TAIR: AT5G03300.1 adenosine kinase 2; Swiss-Prot: sp\|Q9LZG0\|ADK2_ARATH Adenosine kinase 2; TrEMBL-Plants: tr\|I3SE78\|I3SE78_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0080200	GO terms View details of GO:0004001 View details of GO:0006166	2
LotjaGi5g1v0080200.2 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	Adenosine kinase, putative; TAIR: AT5G03300.1 adenosine kinase 2; Swiss-Prot: sp\|Q9LZG0\|ADK2_ARATH Adenosine kinase 2; TrEMBL-Plants: tr\|I3SE78\|I3SE78_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0080200	GO terms View details of GO:0004001 View details of GO:0006166	2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term	Namespace	Name	Observations	Saturation (%)
GO:0006166 View details of GO:0006166 AmiGO InterPro QuickGO	Biological process	Purine ribonucleoside salvage	1	16.67