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Field | Value |
---|---|
Namespace | Molecular function |
Short description | Superoxide dismutase activity |
Full defintion | Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide. |
Subterm of |
The relationship of GO:0004784 with other GO terms.
Relationship type | GO terms |
---|---|
Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0004784, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
---|---|
EC | 1.15.1.1 |
GOC | vw |
PMID | Oxygen and the copper chaperone CCS regulate posttranslational activation of Cu,Zn superoxide dismutase. Proc Natl Acad Sci U S A. 2004 Apr 13; 101 (15): 5518–23.PMID: 15064408 Oxidative stress leads to the up-regulation of many antioxidant enzymes including Cu,Zn superoxide dismutase (SOD1) via transcriptional mechanisms; however, few examples of posttranslational regulation are known. The copper chaperone for SOD1 (CCS) is involved in physiological SOD1 activation, and its primary function is thought to be delivery of copper to the enzyme. Data presented here are consistent with a previously uncharacterized function for CCS in the SOD1 pathway, namely mediating enzyme activation in response to increases in oxygen tension. Activity assays with pure proteins and cell extracts reveal that O(2) (or superoxide) is required for activation of SOD1 by CCS. Dose-response studies with a translational blocking agent demonstrate that the cellular oxidative response to O(2) is multitiered: existing apo-pools of SOD1 are activated by CCS in the early response, followed by increasing expression of SOD1 protein with persistent oxidative stress. This CCS function provides oxidant-responsive posttranslational regulation of SOD1 activity and may be relevant to a wide array of physiological stresses that involve a sudden elevation of oxygen availability. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | PREDICTED: superoxide dismutase [Fe] gi|502134053|ref|XP_004501984.1| | 4 | ||
– | Superoxide dismutase [Medicago truncatula] gi|357497317|ref|XP_003618947.1| | 2 | ||
– | Fe-superoxide dismutase 1 precursor [Lotus japonicus] gi|46402890|gb|AAS92464.1| | 4 | ||
– | Mn-superoxide dismutase [Lotus japonicus] gi|33521626|gb|AAQ20004.1| | 4 | ||
– | Cytosolic CuZn-superoxide dismutase [Lotus japonicus] gi|32441511|gb|AAP81872.1| | 2 | ||
– | Fe-superoxide dismutase 1 precursor [Lotus japonicus] gi|46402890|gb|AAS92464.1| | 4 | ||
– | Superoxide dismutase; TAIR: AT3G10920.1 manganese superoxide dismutase 1; Swiss-Prot: sp|P27084|SODM_PEA Superoxide dismutase [Mn], mitochondrial; TrEMBL-Plants: tr|Q56VR0|Q56VR0_LOTJA Superoxide dismutase; Found in the gene: LotjaGi1g1v0308600 | 4 | ||
– | Superoxide dismutase [Cu]-Zn]; TAIR: AT1G08830.1 copper/zinc superoxide dismutase 1; Swiss-Prot: sp|Q9SQL5|SODC_ANACO Superoxide dismutase [Cu]-Zn]; TrEMBL-Plants: tr|Q56VR6|Q56VR6_LOTJA Superoxide dismutase [Cu]-Zn]; Found in the gene: LotjaGi1g1v0777100 | 2 | ||
– | Superoxide dismutase [Cu]-Zn]; TAIR: AT5G18100.1 copper/zinc superoxide dismutase 3; Swiss-Prot: sp|O49044|SODC2_MESCR Superoxide dismutase [Cu]-Zn] 2; TrEMBL-Plants: tr|I3SMT5|I3SMT5_LOTJA Superoxide dismutase [Cu]-Zn]; Found in the gene: LotjaGi2g1v0106900_LC | 2 | ||
– | Superoxide dismutase; TAIR: AT5G51100.1 Fe superoxide dismutase 2; Swiss-Prot: sp|P28759|SODF_SOYBN Superoxide dismutase [Fe], chloroplastic; TrEMBL-Plants: tr|Q53D71|Q53D71_LOTJA Superoxide dismutase; Found in the gene: LotjaGi5g1v0257700 | 4 | ||
– | Superoxide dismutase; TAIR: AT5G51100.1 Fe superoxide dismutase 2; Swiss-Prot: sp|Q9LU64|SODF2_ARATH Superoxide dismutase [Fe] 2, chloroplastic; TrEMBL-Plants: tr|Q53D73|Q53D73_LOTJA Fe-superoxide dismutase 1; Found in the gene: LotjaGi6g1v0018800 | 4 | ||
– | Superoxide dismutase; TAIR: AT5G23310.1 Fe superoxide dismutase 3; Swiss-Prot: sp|Q9FMX0|SODF3_ARATH Superoxide dismutase [Fe] 3, chloroplastic; TrEMBL-Plants: tr|A0A151R579|A0A151R579_CAJCA Uncharacterized protein; Found in the gene: LotjaGi6g1v0192100 | 4 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Biological process | Oxidation-reduction process | 1 | 8.33 |