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GO:0005672

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description Transcription factor TFIIA complex
Full defintion A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12).
Subterm of

Relationships

The relationship of GO:0005672 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCjl
PMID
A facelift for the general transcription factor TFIIA.Høiby T, Zhou H, Mitsiou DJ, Stunnenberg HG
Biochim Biophys Acta. 2007 Jul-Aug; 1769 (7-8): 429–36.PMID: 17560669

TFIIA was classified as a general transcription factor when it was first identified. Since then it has been debated to what extent it can actually be regarded as "general". The most notable feature of TFIIA is the proteolytical cleavage of the TFIIAalphabeta into a TFIIAalpha and TFIIAbeta moiety which has long remained a mystery. Recent studies have showed that TFIIA is cleaved by Taspase1 which was initially identified as the protease for the proto-oncogene MLL. Cleavage of TFIIA does not appear to serve as a step required for its activation as the uncleaved TFIIA in the Taspase1 knock-outs adequately support bulk transcription. Instead, cleavage of TFIIA seems to affect its turn-over and may be a part of an intricate degradation mechanism that allows fine-tuning of cellular levels of TFIIA. Cleavage might also be responsible for switching transcription program as the uncleaved and cleaved TFIIA might have distinct promoter specificity during development and differentiation. This review will focus on functional characteristics of TFIIA and discuss novel insights in the role of this elusive transcription factor.

Associated Lotus transcripts 9

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj1g3v0180960.1
– Transcription initiation factor IIA subunit [Medicago truncatula] gi|357501375|ref|XP_003620976.1|
GO terms
2
Lj1g3v0180960.2
– PREDICTED: transcription initiation factor IIA subunit 2-like [Cucumis sativus] gi|449441770|ref|XP_004138655.1|
GO terms
2
Lj3g3v1680410.1
– PREDICTED: transcription initiation factor IIA large subunit-like [Cicer arietinum] gi|502081823|ref|XP_004486980.1|
GO terms
2
Lj3g3v3235420.1
– PREDICTED: transcription initiation factor IIA large subunit-like [Cicer arietinum] gi|502081823|ref|XP_004486980.1|
GO terms
2
LotjaGi1g1v0135200.1
– Transcription initiation factor IIA subunit 2; TAIR: AT4G24440.1 transcription initiation factor IIA gamma chain / TFIIA-gamma (TFIIA-S); Swiss-Prot: sp|Q39236|T2AG_ARATH Transcription initiation factor IIA subunit 2; TrEMBL-Plants: tr|I3S8P2|I3S8P2_LOTJA Transcription initiation factor IIA subunit 2; Found in the gene: LotjaGi1g1v0135200
GO terms
2
LotjaGi1g1v0135200.2
– Transcription initiation factor IIA subunit 2; TAIR: AT4G24440.1 transcription initiation factor IIA gamma chain / TFIIA-gamma (TFIIA-S); Swiss-Prot: sp|Q39236|T2AG_ARATH Transcription initiation factor IIA subunit 2; TrEMBL-Plants: tr|I3S8P2|I3S8P2_LOTJA Transcription initiation factor IIA subunit 2; Found in the gene: LotjaGi1g1v0135200
GO terms
2
LotjaGi3g1v0286400.1
– Transcription initiation factor IIA large subunit; TAIR: AT1G07470.1 Transcription factor IIA, alpha/beta subunit; Swiss-Prot: sp|Q9USU9|TOA1_SCHPO Transcription initiation factor IIA large subunit; TrEMBL-Plants: tr|A0A0B2RCP3|A0A0B2RCP3_GLYSO Transcription initiation factor IIA large subunit; Found in the gene: LotjaGi3g1v0286400
GO terms
2
LotjaGi3g1v0286400.2
– Transcription initiation factor IIA large subunit; TAIR: AT1G07470.1 Transcription factor IIA, alpha/beta subunit; Swiss-Prot: sp|Q9USU9|TOA1_SCHPO Transcription initiation factor IIA large subunit; TrEMBL-Plants: tr|A0A0B2RCP3|A0A0B2RCP3_GLYSO Transcription initiation factor IIA large subunit; Found in the gene: LotjaGi3g1v0286400
GO terms
2
LotjaGi3g1v0490400.1
– Transcription initiation factor IIA large subunit; TAIR: AT1G07480.1 Transcription factor IIA, alpha/beta subunit; Swiss-Prot: sp|Q9USU9|TOA1_SCHPO Transcription initiation factor IIA large subunit; TrEMBL-Plants: tr|V7BZ67|V7BZ67_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0490400
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0006367
Biological process Transcription initiation from RNA polymerase II promoter 1 11.11