Gene Ontology — View

Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

GO:0005784

Overview

Field	Value
Namespace	Cellular component
Short description	Sec61 translocon complex
Full defintion	A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events.
Subterm of	GO:0071256

Relationships

The relationship of GO:0005784 with other GO terms.

Relationship type	GO terms
Is a	GO:0071256
Regulates	n.a.
Part of	n.a.
Positively regulates	n.a.
Negatively regulates	n.a.

Ancestor tree

A force layout showing the ancestor tree for GO:0005784, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.

Drag and drop nodes to manually position (i.e. fix) them
Double click on a node to unfix the node
Press Alt and double click to visit the page containing further details of a GO term
Right clicking on a node will reveal a context menu

Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field	Value
GOC	mah
PMID	The expanding role of the ER translocon in membrane protein folding.Skach WR J Cell Biol. 2007 Dec 31; 179 (7): 1333–5.PMID: 18166647 Eukaryotic polytopic membrane proteins are cotranslationally inserted into the ER membrane by a multisubunit protein-conducting channel called the Sec61 translocon. Although most major translocon components have been identified and reconstituted, their stoichiometry and functional organization remain unknown. This has led to speculative and sometimes conflicting models describing how multiple transmembrane (TM) segments might be oriented and integrated during nascent polytopic protein biogenesis. Kida et al. (see p. 1441 of this issue) shed new insight into this area by demonstrating that functional translocons exhibit a remarkable flexibility by simultaneously accommodating at least two hydrophilic translocating peptides that are separated by multiple hydrophobic TMs. These surprising findings support an expanded role for the translocon in membrane protein biogenesis and require reassessment of current views based on a single small functional pore.

Field

Value

GOC

mah

PMID

The expanding role of the ER translocon in membrane protein folding.Skach WR
J Cell Biol. 2007 Dec 31; 179 (7): 1333–5.PMID: 18166647

Eukaryotic polytopic membrane proteins are cotranslationally inserted into the ER membrane by a multisubunit protein-conducting channel called the Sec61 translocon. Although most major translocon components have been identified and reconstituted, their stoichiometry and functional organization remain unknown. This has led to speculative and sometimes conflicting models describing how multiple transmembrane (TM) segments might be oriented and integrated during nascent polytopic protein biogenesis. Kida et al. (see p. 1441 of this issue) shed new insight into this area by demonstrating that functional translocons exhibit a remarkable flexibility by simultaneously accommodating at least two hydrophilic translocating peptides that are separated by multiple hydrophobic TMs. These surprising findings support an expanded role for the translocon in membrane protein biogenesis and require reassessment of current views based on a single small functional pore.

Associated Lotus transcripts 3

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Transcript	Name	Description	GO terms	GO count
Lj0g3v0131319.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	PREDICTED: protein transport protein Sec61 subunit beta-like isoform 1 [Cucumis sativus] gi\|449431966\|ref\|XP_004133771.1\|	GO terms View details of GO:0005784 View details of GO:0006886	2
LotjaGi1g1v0112200.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	Protein transport protein Sec61 subunit beta; TAIR: AT3G60540.1 Preprotein translocase Sec, Sec61-beta subunit protein; Swiss-Prot: sp\|P38389\|SC61B_ARATH Protein transport protein Sec61 subunit beta; TrEMBL-Plants: tr\|I3T8K1\|I3T8K1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0112200	GO terms View details of GO:0005784 View details of GO:0006886	2
LotjaGi3g1v0204500.1 View transcript LORE1 insertions in MG20 v3.0 Genome browser Expression Atlas (ExpAt)	–	Protein transport protein Sec61 subunit beta; TAIR: AT3G60540.1 Preprotein translocase Sec, Sec61-beta subunit protein; Swiss-Prot: sp\|P38389\|SC61B_ARATH Protein transport protein Sec61 subunit beta; TrEMBL-Plants: tr\|I3SVM8\|I3SVM8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0204500	GO terms View details of GO:0005784 View details of GO:0006886	2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term	Namespace	Name	Observations	Saturation (%)
GO:0006886 View details of GO:0006886 AmiGO InterPro QuickGO	Biological process	Intracellular protein transport	1	33.33