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GO:0006890

View this GO term in other databases

Overview

Field Value
Namespace Biological process
Short description Retrograde vesicle-mediated transport, Golgi to ER
Full defintion The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.
Subterm of

Relationships

The relationship of GO:0006890 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
ISBN
Molecular Cell BiologyMolecular Cell Biology

Harvey F. Lodish · ISBN: 0716731363

Scientific American Library, 2000 · 1192 pages

With its acclaimed author team, cutting-edge content, emphasis on medical relevance, and coverage based on landmark experiments, "Molecular Cell Biology" has justly earned an impeccable reputation as an authoritative and exciting text. The new Sixth Edition features two new coauthors, expanded coverage of immunology and development, and new media tools for students and instructors.

PMID
COG-7-deficient Human Fibroblasts Exhibit Altered Recycling of Golgi Proteins.Steet R, Kornfeld S
Mol Biol Cell. 2006 May; 17 (5): 2312–21.PMID: 16510524

Recently, we reported that two siblings presenting with the clinical syndrome congenital disorders of glycosylation (CDG) have mutations in the gene encoding Cog7p, a member of the conserved oligomeric Golgi (COG) complex. In this study, we analyzed the localization and trafficking of multiple Golgi proteins in patient fibroblasts under a variety of conditions. Although the immunofluorescent staining pattern of several Golgi proteins was indistinguishable from normal, the staining of endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC)-53 and the vesicular-soluble N-ethylmaleimide-sensitive factor attachment protein receptors GS15 and GS28 was abnormal, and the steady-state level of GS15 was greatly decreased. Retrograde transport of multiple Golgi proteins to the ER in patient fibroblasts via brefeldin A-induced tubules was significantly slower than occurs in normal fibroblasts, whereas anterograde protein trafficking was much less affected. After prolonged treatment with brefeldin A, several Golgi proteins were detected in clusters that colocalize with the microtubule-organizing center in patient cells. All of these abnormalities were normalized in COG7-corrected patient fibroblasts. These results serve to better define the role of the COG complex in facilitating protein trafficking between the Golgi and ER and provide a diagnostic framework for the identification of CDG defects involving trafficking proteins.

Associated Lotus transcripts 49

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0038999.1
– PREDICTED: transmembrane protein 115-like [Glycine max] gi|356498564|ref|XP_003518120.1|
GO terms
2
Lj0g3v0047429.1
– Neuroblastoma-amplified sequence [Medicago truncatula] gi|357464029|ref|XP_003602296.1|
GO terms
1
Lj0g3v0047429.2
– Neuroblastoma-amplified sequence [Medicago truncatula] gi|357464029|ref|XP_003602296.1|
GO terms
1
Lj0g3v0047429.3
– Neuroblastoma-amplified sequence [Medicago truncatula] gi|357464029|ref|XP_003602296.1|
GO terms
1
Lj0g3v0061899.1
– PREDICTED: novel plant SNARE 11-like [Fragaria vesca subsp]. vesca] gi|470128757|ref|XP_004300301.1|
GO terms
2
Lj0g3v0190289.1
– PREDICTED: vesicle transport protein SEC20-like isoform X1 [Cicer arietinum] gi|502079957|ref|XP_004486418.1|
GO terms
2
Lj1g3v1019010.1
– Neuroblastoma-amplified sequence [Medicago truncatula] gi|357464029|ref|XP_003602296.1|
GO terms
1
Lj3g3v1295850.1
– PREDICTED: vesicle transport protein SEC20-like isoform X1 [Cicer arietinum] gi|502079957|ref|XP_004486418.1|
GO terms
2
Lj4g3v0071010.1
– PREDICTED: vesicle transport protein SEC20-like isoform X1 [Cicer arietinum] gi|502079957|ref|XP_004486418.1|
GO terms
2
Lj4g3v2249070.1
– PREDICTED: novel plant SNARE 13-like [Glycine max] gi|356565471|ref|XP_003550963.1|
GO terms
2
Lj5g3v2237630.1
– Coatomer subunit delta-3 [Medicago truncatula] gi|357454817|ref|XP_003597689.1|
GO terms
2
Lj5g3v2237630.2
– Coatomer subunit delta-3 [Medicago truncatula] gi|357454817|ref|XP_003597689.1|
GO terms
2
Lj5g3v2256170.1
– PREDICTED: coatomer subunit delta-like [Glycine max] gi|356545133|ref|XP_003540999.1|
GO terms
2
Lj5g3v2256170.2
– PREDICTED: coatomer subunit delta-like isoform X1 [Cicer arietinum] gi|502120970|ref|XP_004497143.1|
GO terms
2
Lj6g3v1588730.1
– PREDICTED: coatomer subunit epsilon-1-like [Cicer arietinum] gi|502080269|ref|XP_004486511.1|
GO terms
2
Lj6g3v1588730.2
– PREDICTED: coatomer subunit epsilon-1-like [Cicer arietinum] gi|502080269|ref|XP_004486511.1|
GO terms
2
LotjaGi1g1v0291300.1
– Neuroblastoma-amplified sequence; TAIR: AT5G24350.1 neuroblastoma-amplified sequence protein; Swiss-Prot: sp|Q9FIN7|MIP2_ARATH MAG2-interacting protein 2; TrEMBL-Plants: tr|I1KAW5|I1KAW5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0291300
GO terms
1
LotjaGi1g1v0291300.2
– Neuroblastoma-amplified sequence; TAIR: AT5G24350.1 neuroblastoma-amplified sequence protein; Swiss-Prot: sp|Q9FIN7|MIP2_ARATH MAG2-interacting protein 2; TrEMBL-Plants: tr|I1KAW5|I1KAW5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0291300
GO terms
1
LotjaGi1g1v0291300.3
– Neuroblastoma-amplified sequence; TAIR: AT5G24350.1 neuroblastoma-amplified sequence protein; Swiss-Prot: sp|Q9FIN7|MIP2_ARATH MAG2-interacting protein 2; TrEMBL-Plants: tr|K7KLV4|K7KLV4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0291300
GO terms
1
LotjaGi1g1v0291300.4
– Neuroblastoma-amplified sequence; TAIR: AT5G24350.1 neuroblastoma-amplified sequence protein; Swiss-Prot: sp|Q9FIN7|MIP2_ARATH MAG2-interacting protein 2; TrEMBL-Plants: tr|A0A0R0KIZ5|A0A0R0KIZ5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0291300
GO terms
1
LotjaGi1g1v0291300.5
– Neuroblastoma-amplified sequence; TAIR: AT5G24350.1 neuroblastoma-amplified sequence protein; Swiss-Prot: sp|Q9FIN7|MIP2_ARATH MAG2-interacting protein 2; TrEMBL-Plants: tr|K7KLV4|K7KLV4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0291300
GO terms
1
LotjaGi1g1v0499100.1
– Coatomer subunit zeta; TAIR: AT4G08520.1 SNARE-like superfamily protein; Swiss-Prot: sp|Q8H1F4|COPZ3_ARATH Coatomer subunit zeta-3; TrEMBL-Plants: tr|A0A151SUF4|A0A151SUF4_CAJCA Coatomer subunit zeta-3; Found in the gene: LotjaGi1g1v0499100
GO terms
2
LotjaGi1g1v0499100.2
– Coatomer subunit zeta; TAIR: AT4G08520.1 SNARE-like superfamily protein; Swiss-Prot: sp|Q8H1F4|COPZ3_ARATH Coatomer subunit zeta-3; TrEMBL-Plants: tr|A0A151SUF4|A0A151SUF4_CAJCA Coatomer subunit zeta-3; Found in the gene: LotjaGi1g1v0499100
GO terms
2
LotjaGi2g1v0102900.1
– Transmembrane protein 115; TAIR: AT3G07950.1 rhomboid protein-like protein; Swiss-Prot: sp|Q8LF05|RBL19_ARATH Rhomboid-like protein 19; TrEMBL-Plants: tr|I3SV60|I3SV60_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0102900
GO terms
2
LotjaGi3g1v0184500.1
– Protein transport protein sec20; TAIR: AT3G24315.1 Sec20 family protein; Swiss-Prot: sp|Q6QD59|SEC20_MOUSE Vesicle transport protein SEC20; TrEMBL-Plants: tr|C6TKD1|C6TKD1_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0184500
GO terms
2
LotjaGi3g1v0284200_LC.1
– Transmembrane protein 115; TAIR: AT3G07950.1 rhomboid protein-like protein; Swiss-Prot: sp|Q8LF05|RBL19_ARATH Rhomboid-like protein 19; TrEMBL-Plants: tr|G7I9J5|G7I9J5_MEDTR Transmembrane protein, putative; Found in the gene: LotjaGi3g1v0284200_LC
GO terms
2
LotjaGi3g1v0357600.1
– Coatomer subunit zeta; TAIR: AT1G15370.1 SNARE-like superfamily protein; Swiss-Prot: sp|Q9MAX5|COPZ1_ORYSJ Coatomer subunit zeta-1; TrEMBL-Plants: tr|I3S581|I3S581_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0357600
GO terms
2
LotjaGi3g1v0422300.1
– Coatomer subunit zeta; TAIR: AT4G08520.1 SNARE-like superfamily protein; Swiss-Prot: sp|Q8H1F4|COPZ3_ARATH Coatomer subunit zeta-3; TrEMBL-Plants: tr|A0A151SHM4|A0A151SHM4_CAJCA Coatomer subunit zeta-2; Found in the gene: LotjaGi3g1v0422300
GO terms
2
LotjaGi3g1v0422300.2
– Coatomer subunit zeta; TAIR: AT3G09800.1 SNARE-like superfamily protein; Swiss-Prot: sp|Q84LG4|COPZ2_ARATH Coatomer subunit zeta-2; TrEMBL-Plants: tr|A0A151SHM4|A0A151SHM4_CAJCA Coatomer subunit zeta-2; Found in the gene: LotjaGi3g1v0422300
GO terms
2
LotjaGi3g1v0422300.3
– Coatomer subunit zeta; TAIR: AT3G09800.1 SNARE-like superfamily protein; Swiss-Prot: sp|Q84LG4|COPZ2_ARATH Coatomer subunit zeta-2; TrEMBL-Plants: tr|A0A151SHM4|A0A151SHM4_CAJCA Coatomer subunit zeta-2; Found in the gene: LotjaGi3g1v0422300
GO terms
2
LotjaGi3g1v0422300.4
– Coatomer subunit zeta; TAIR: AT3G09800.1 SNARE-like superfamily protein; Swiss-Prot: sp|Q84LG4|COPZ2_ARATH Coatomer subunit zeta-2; TrEMBL-Plants: tr|A0A151SHM4|A0A151SHM4_CAJCA Coatomer subunit zeta-2; Found in the gene: LotjaGi3g1v0422300
GO terms
2
LotjaGi4g1v0193400.1
– SNARE; TAIR: AT2G35190.1 Putative plant snare 11; Swiss-Prot: sp|Q944A9|NPS11_ARATH Novel plant SNARE 11; TrEMBL-Plants: tr|I1MV96|I1MV96_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0193400
GO terms
2
LotjaGi4g1v0313500.1
– Novel plant snare, putative; TAIR: AT3G17440.1 Putative plant snare 13; Swiss-Prot: sp|Q9LRP1|NPS13_ARATH Novel plant SNARE 13; TrEMBL-Plants: tr|I3SMK2|I3SMK2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0313500
GO terms
2
LotjaGi4g1v0313500.2
– SNARE; TAIR: AT1G48240.1 Putative plant snare 12; Swiss-Prot: sp|Q9LNH6|NPS12_ARATH Novel plant SNARE 12; TrEMBL-Plants: tr|I3SMK2|I3SMK2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0313500
GO terms
2
LotjaGi5g1v0275700.1
– Transmembrane protein 115; TAIR: AT3G07950.1 rhomboid protein-like protein; Swiss-Prot: sp|Q8LF05|RBL19_ARATH Rhomboid-like protein 19; TrEMBL-Plants: tr|G7I9J5|G7I9J5_MEDTR Transmembrane protein, putative; Found in the gene: LotjaGi5g1v0275700
GO terms
2
LotjaGi5g1v0275700.2
– Transmembrane protein 115; TAIR: AT3G07950.1 rhomboid protein-like protein; Swiss-Prot: sp|Q8LF05|RBL19_ARATH Rhomboid-like protein 19; TrEMBL-Plants: tr|G7I9J5|G7I9J5_MEDTR Transmembrane protein, putative; Found in the gene: LotjaGi5g1v0275700
GO terms
2
LotjaGi5g1v0343900.1
– Coatomer subunit delta-like protein; TAIR: AT5G05010.1 clathrin adaptor complexes medium subunit family protein; Swiss-Prot: sp|Q93Y22|COPD_ARATH Coatomer subunit delta; TrEMBL-Plants: tr|G7II11|G7II11_MEDTR Coatomer subunit delta-like protein; Found in the gene: LotjaGi5g1v0343900
GO terms
2
LotjaGi5g1v0343900.2
– Coatomer subunit delta-like protein; TAIR: AT5G05010.1 clathrin adaptor complexes medium subunit family protein; Swiss-Prot: sp|Q93Y22|COPD_ARATH Coatomer subunit delta; TrEMBL-Plants: tr|G7II11|G7II11_MEDTR Coatomer subunit delta-like protein; Found in the gene: LotjaGi5g1v0343900
GO terms
2
LotjaGi5g1v0350800.1
– Coatomer subunit delta-like protein; TAIR: AT5G05010.1 clathrin adaptor complexes medium subunit family protein; Swiss-Prot: sp|Q93Y22|COPD_ARATH Coatomer subunit delta; TrEMBL-Plants: tr|A0A1J7FSC8|A0A1J7FSC8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0350800
GO terms
2
LotjaGi5g1v0350800.2
– Coatomer subunit delta-like protein; TAIR: AT5G05010.1 clathrin adaptor complexes medium subunit family protein; Swiss-Prot: sp|Q93Y22|COPD_ARATH Coatomer subunit delta; TrEMBL-Plants: tr|A0A1J7FSC8|A0A1J7FSC8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0350800
GO terms
2
LotjaGi5g1v0350800.3
– Coatomer subunit delta-like protein; TAIR: AT5G05010.1 clathrin adaptor complexes medium subunit family protein; Swiss-Prot: sp|Q93Y22|COPD_ARATH Coatomer subunit delta; TrEMBL-Plants: tr|A0A1J7FSC8|A0A1J7FSC8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0350800
GO terms
2
LotjaGi6g1v0264200.1
– Coatomer epsilon subunit; TAIR: AT1G30630.1 Coatomer epsilon subunit; Swiss-Prot: sp|Q9SA78|COPE1_ARATH Coatomer subunit epsilon-1; TrEMBL-Plants: tr|A0A0S3S4G6|A0A0S3S4G6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0264200
GO terms
2
LotjaGi6g1v0264200.2
– Coatomer epsilon subunit; TAIR: AT1G30630.1 Coatomer epsilon subunit; Swiss-Prot: sp|Q9SA78|COPE1_ARATH Coatomer subunit epsilon-1; TrEMBL-Plants: tr|Q9MAX8|Q9MAX8_SOYBN Epsilon1-COP; Found in the gene: LotjaGi6g1v0264200
GO terms
2
LotjaGi6g1v0264200.3
– Coatomer epsilon subunit; TAIR: AT1G30630.1 Coatomer epsilon subunit; Swiss-Prot: sp|Q9SA78|COPE1_ARATH Coatomer subunit epsilon-1; TrEMBL-Plants: tr|A0A0S3S4G6|A0A0S3S4G6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0264200
GO terms
2
LotjaGi6g1v0264200.4
– Coatomer epsilon subunit; TAIR: AT1G30630.1 Coatomer epsilon subunit; Swiss-Prot: sp|Q9SA78|COPE1_ARATH Coatomer subunit epsilon-1; TrEMBL-Plants: tr|Q9MAX8|Q9MAX8_SOYBN Epsilon1-COP; Found in the gene: LotjaGi6g1v0264200
GO terms
2
LotjaGi6g1v0264200.5
– Coatomer epsilon subunit; TAIR: AT1G30630.1 Coatomer epsilon subunit; Swiss-Prot: sp|Q9SA78|COPE1_ARATH Coatomer subunit epsilon-1; TrEMBL-Plants: tr|K7MB75|K7MB75_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0264200
GO terms
2
LotjaGi6g1v0276600.1
– Coatomer subunit zeta; TAIR: AT1G60970.1 SNARE-like superfamily protein; Swiss-Prot: sp|Q6Z844|COPZ2_ORYSJ Coatomer subunit zeta-2; TrEMBL-Plants: tr|I3TAJ3|I3TAJ3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0276600
GO terms
2
LotjaGi6g1v0276600.2
– Coatomer subunit zeta; TAIR: AT1G60970.1 SNARE-like superfamily protein; Swiss-Prot: sp|Q6Z844|COPZ2_ORYSJ Coatomer subunit zeta-2; TrEMBL-Plants: tr|I3TAJ3|I3TAJ3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0276600
GO terms
2
LotjaGi6g1v0276900.1
– Protein transport protein sec20; TAIR: AT3G24315.1 Sec20 family protein; Swiss-Prot: sp|Q6QD59|SEC20_MOUSE Vesicle transport protein SEC20; TrEMBL-Plants: tr|C6TKD1|C6TKD1_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi6g1v0276900
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0006890
Biological process Retrograde vesicle-mediated transport, Golgi to ER 1 2.04