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GO:0008180

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description COP9 signalosome
Full defintion A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
Subterm of

Relationships

The relationship of GO:0008180 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
The COP9 signalosome.Wei N, Deng XW
Annu Rev Cell Dev Biol. 2003; 19 (): 261–86.PMID: 14570571

The COP9 signalosome (CSN) is composed of eight distinct subunits and is highly homologous to the lid sub-complex of the 26S proteasome. CSN was initially defined as a repressor of photomorphogenesis in Arabidopsis, and it has now been found to participate in diverse cellular and developmental processes in various eukaryotic organisms. Recently, CSN was revealed to have a metalloprotease activity centered in the CSN5/Jab1 subunit, which removes the post-translational modification of a ubiquitin-like protein, Nedd8/Rub1, from the cullin component of SCF ubiquitin E3 ligase (i.e., de-neddylation). In addition, CSN is associated with de-ubiquitination activity and protein kinase activities capable of phosphorylating important signaling regulators. The involvement of CSN in a number of cellular and developmental processes has been attributed to its control over ubiquitin-proteasome-mediated protein degradation.

Associated Lotus transcripts 19

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0098349.1
– PREDICTED: COP9 signalosome complex subunit 1-like [Glycine max] gi|356505043|ref|XP_003521302.1|
GO terms
2
Lj0g3v0320179.1
– PREDICTED: COP9 signalosome complex subunit 6a-like [Cicer arietinum] gi|502127367|ref|XP_004499677.1|
GO terms
2
Lj6g3v1653280.1
– PREDICTED: COP9 signalosome complex subunit 8 [Vitis vinifera] gi|225447785|ref|XP_002266060.1|
GO terms
3
Lj6g3v1653280.2
– PREDICTED: COP9 signalosome complex subunit 8 [Vitis vinifera] gi|225447785|ref|XP_002266060.1|
GO terms
3
Lj6g3v2255760.1
– PREDICTED: COP9 signalosome complex subunit 8-like isoform X1 [Cicer arietinum] gi|502077005|ref|XP_004485521.1|
GO terms
3
LotjaGi1g1v0393500.1
– COP9 signalosome complex subunit 5; TAIR: AT1G71230.1 COP9-signalosome 5B; Swiss-Prot: sp|Q9FVU9|CSN5A_ARATH COP9 signalosome complex subunit 5a; TrEMBL-Plants: tr|G7JCC9|G7JCC9_MEDTR COP9 signalosome complex subunit 5; Found in the gene: LotjaGi1g1v0393500
GO terms
2
LotjaGi1g1v0393500.2
– COP9 signalosome complex subunit 5; TAIR: AT1G71230.1 COP9-signalosome 5B; Swiss-Prot: sp|Q9FVU9|CSN5A_ARATH COP9 signalosome complex subunit 5a; TrEMBL-Plants: tr|G7JCC9|G7JCC9_MEDTR COP9 signalosome complex subunit 5; Found in the gene: LotjaGi1g1v0393500
GO terms
2
LotjaGi1g1v0496000.1
– COP9 signalosome complex subunit-like protein; TAIR: AT1G02090.1 Proteasome component (PCI) domain protein; Swiss-Prot: sp|Q94JU3|CSN7_ARATH COP9 signalosome complex subunit 7; TrEMBL-Plants: tr|A0A0S3SAE1|A0A0S3SAE1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0496000
GO terms
2
LotjaGi1g1v0496000.2
– COP9 signalosome complex subunit-like protein; TAIR: AT1G02090.2 Proteasome component (PCI) domain protein; Swiss-Prot: sp|Q94JU3|CSN7_ARATH COP9 signalosome complex subunit 7; TrEMBL-Plants: tr|A0A0S3SAE1|A0A0S3SAE1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0496000
GO terms
2
LotjaGi3g1v0331000.1
– Eukaryotic translation initiation factor 3 subunit F; TAIR: AT5G56280.1 COP9 signalosome subunit 6A; Swiss-Prot: sp|Q8W206|CSN6A_ARATH COP9 signalosome complex subunit 6a; TrEMBL-Plants: tr|I3S7E3|I3S7E3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0331000
GO terms
2
LotjaGi3g1v0553000.1
– COP9 signalosome complex subunit 4; TAIR: AT5G42970.1 Proteasome component (PCI) domain protein; Swiss-Prot: sp|Q8L5U0|CSN4_ARATH COP9 signalosome complex subunit 4; TrEMBL-Plants: tr|I1L5P9|I1L5P9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0553000
GO terms
1
LotjaGi3g1v0553000.2
– COP9 signalosome complex subunit-like protein; TAIR: AT5G42970.1 Proteasome component (PCI) domain protein; Swiss-Prot: sp|Q8L5U0|CSN4_ARATH COP9 signalosome complex subunit 4; TrEMBL-Plants: tr|A0A151TLK9|A0A151TLK9_CAJCA COP9 signalosome complex subunit 4; Found in the gene: LotjaGi3g1v0553000
GO terms
1
LotjaGi3g1v0553000.3
– COP9 signalosome complex subunit-like protein; TAIR: AT5G42970.1 Proteasome component (PCI) domain protein; Swiss-Prot: sp|Q8L5U0|CSN4_ARATH COP9 signalosome complex subunit 4; TrEMBL-Plants: tr|A0A151TLK9|A0A151TLK9_CAJCA COP9 signalosome complex subunit 4; Found in the gene: LotjaGi3g1v0553000
GO terms
1
LotjaGi3g1v0553000.4
– COP9 signalosome complex subunit 4; TAIR: AT5G42970.1 Proteasome component (PCI) domain protein; Swiss-Prot: sp|Q8L5U0|CSN4_ARATH COP9 signalosome complex subunit 4; TrEMBL-Plants: tr|I1L5P9|I1L5P9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0553000
GO terms
1
LotjaGi3g1v0553000.5
– COP9 signalosome complex subunit 4; TAIR: AT5G42970.1 Proteasome component (PCI) domain protein; Swiss-Prot: sp|Q8L5U0|CSN4_ARATH COP9 signalosome complex subunit 4; TrEMBL-Plants: tr|I1L5P9|I1L5P9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0553000
GO terms
1
LotjaGi3g1v0553000.6
– COP9 signalosome complex subunit 4; TAIR: AT5G42970.1 Proteasome component (PCI) domain protein; Swiss-Prot: sp|Q8L5U0|CSN4_ARATH COP9 signalosome complex subunit 4; TrEMBL-Plants: tr|I3RZF8|I3RZF8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0553000
GO terms
1
LotjaGi6g1v0357400.1
– COP9 signalosome complex subunit 8; TAIR: AT4G14110.1 COP9 signalosome, subunit CSN8; Swiss-Prot: sp|P43255|CSN8_ARATH COP9 signalosome complex subunit 8; TrEMBL-Plants: tr|I3SY35|I3SY35_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0357400
GO terms
3
LotjaGi6g1v0357400.2
– COP9 signalosome complex subunit 8; TAIR: AT4G14110.1 COP9 signalosome, subunit CSN8; Swiss-Prot: sp|P43255|CSN8_ARATH COP9 signalosome complex subunit 8; TrEMBL-Plants: tr|I3SY35|I3SY35_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0357400
GO terms
3
LotjaGi6g1v0357400.3
– COP9 signalosome complex subunit 8; TAIR: AT4G14110.1 COP9 signalosome, subunit CSN8; Swiss-Prot: sp|P43255|CSN8_ARATH COP9 signalosome complex subunit 8; TrEMBL-Plants: tr|I3SY35|I3SY35_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0357400
GO terms
3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0010387
Biological process COP9 signalosome assembly 1 5.26